Basic information
- CAS
16867-03-1- Standard SMILES
Nc1ncccc1O- InChIKey
BMTSZVZQNMNPCT-UHFFFAOYSA-N- Molecular formula
- C5H6N2O
- Average molar mass
- 110.11 g/mol
- Monoisotopic mass
- 110.04801281
Overview
2-amino-3-hydroxypyridine is a monohydroxypyridine and an aminopyridine.
Names & identifiers
- Preferred name
- 2-Amino-3-Hydroxypyridine
- IUPAC
- 2-aminopyridin-3-ol
- English name
- 2-Amino-3-hydroxypyridine
- Molecular formula
- C5H6N2O
- Molecular weight
- 110.11
Names & synonyms
2-AMINO-3-HYDROXYPYRIDINE16867-03-12-Amino-3-pyridinol3-Pyridinol, 2-amino-3-Hydroxy-2-pyridinamine3-HYDROXY-2-AMINOPYRIDINE3-Pyridinol, 2-aminoP8740PEW4BJAROCOL 2A3HPRODOL 2A3PYRNSC-136806DTXSID50168588
Show more names
2-amino-3-pyridi2-amino-3-pyridino2-Amino-3-hydroxypyrFampridine Impurity 11Dopexamine Impurity 142-Amino-3-pyridinol 13C
RefChem:85129DTXCID4091079240-886-82-Aminopyridin-3-ol2-amino-pyridin-3-olMFCD000063172-Amino-3-pyridolPaliperidone Impurity 25
Database identifiers
- CAS
16867-03-1- PubChem CID
- 28114
- DTXSID
DTXSID50168588- ChEMBL
CHEMBL4777856- ChEBI
CHEBI:195501- UNII
- P8740PEW4B
- EC Number
- 240-886-8
- Nikkaji
- J207.966F
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 59.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 76.8
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (2-Amino-3-Hydroxypyridine) -> CIR (Cosmetic Ingredient Review)
Hair dyeing
Physicochemical properties
- Melting point
- 168 · 168-172 °C (lit.)
- Boiling point
- 206.4 °C · 206.4°C (rough estimate)
- Density
- 1.2111 · 1.2111 (rough estimate)
- vapor pressure
- 0.007 · 0.007-0.28Pa at 20-50℃
- refractive index
- 1.48 · 1.4800 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 5.15 · 5.15±0.10(Predicted)
- form
- Crystalline Powder
- color
- Grayish-beige to brownish
- BRN
- 109868 · 109868
- Cosmetics Ingredients Functions
- HAIR DYEING
- Cosmetic Ingredient Review (CIR)
- 2 · 2-Amino-3-hydroxypyridine (16867-03-1)
- InChI
- 1S/C5H6N2O/c6-5-4(8)2-1-3-7-5/h1-3,8H,(H2,6,7)
- InChIKey
- BMTSZVZQNMNPCT-UHFFFAOYSA-N
- SMILES
- Nc1ncccc1O
- LogP
- -0.25 at · -0.25 at 23℃ and pH7.02-7.04
- Surface tension
- 72.6 mN/m · 72.6mN/m at 1.053g/L and 20℃
- CAS DataBase Reference
- 16867 · 16867-03-1(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1-3
- FDA UNII
- 8740 PEW4B · P8740PEW4B
- NIST Chemistry Reference
- 2 · 2-Amino-3-hydroxypyridine(16867-03-1)
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301-H315-H319
- Precautionary statements
- 301 · P301+P310+P330-P302+P352-P305+P351+P338
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36 · 36/37/38-25-40
- Safety Statements
- 26 · 26-45-37/39-28A-36-22
- RIDADR
- 2811 · UN2811
- WGK Germany
- 3 · 3
- Hazard Note
- Irritant
- HazardClass
- 6.1 · 6.1
- PackingGroup
- III
- HS Code
- 29333999 · 29333999
- Storage Class
- 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- 3 OralEye · Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Danger
H301 (15.7%): Toxic if swallowed [Danger Acute toxicity, oral]
P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 191 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: 3-Pyridinol, 2-amino-
Status: Active Update: 25-09-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/20708
2-Amino-3-hydroxypyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 3 (15.7%)
Toxicology
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- ridadr
- UN2811
- hs_code
- 29333999
- risk_code
- 36/37/38-25-40
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- Xi,T,Xn
- hazard_note
- Irritant
- safety_code
- 26-45-37/39-28A-36-22
- hazard_class
- 6.1
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- packing_group
- III
- Hazard statements
- H301-H315-H319
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2
- Precautionary statements
- P301+P310+P330-P302+P352-P305+P351+P338
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: 2-Amino-3-Hydroxypyridine
Household ProductsInformation on 21 consumer products that contain 2-Amino-3-hydroxypyridine in the following categories is provided:
Use ClassificationCosmetics -> Hair dyeing
Applications
Uses2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.
General Description2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
杭州布朗生物医药科技有限公司15967138206
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
Syntechem Co.,Ltd[email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
上海德默医药科技有限公司400-021-7337 2355568890 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
北京亿思研科技开发中心010-56645598 13366904824 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]
上海景颜化工科技有限公司13817811078 · [email protected]
嘉兴市艾森化工有限公司0573-85285100 18627885956 · [email protected]
Pure Chemistry Scientific Inc.001-857-928-2050 or 1-888-588-9418 · [email protected]
上海隆盛化工有限公司58099637 13585536065 · [email protected]
上海攀鸿化工科技有限公司021-56491756 13512199871 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
南京蓝白化工有限公司025-85499326 15366059326;13813836665 · [email protected]
衡水瑞森化工科技有限公司0318-8888981 13785822979
孝感深远化工有限公司15527621225; 15527621225 · [email protected]
苏州施亚生物科技有限公司86(512)5235 8471 17715136450 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
上海耐士化工科技有限公司400-188-0725 +86 21 34310725 13611771617
天津希恩思生化科技有限公司400 638 7771 · [email protected]
南京维奥化工有限公司Please Send Email 18652950785 · [email protected]
河南多贝化工有限公司0370-2785118 17550508557 · [email protected]
上海源叶生物科技有限公司13636370518 · [email protected]
深圳菲斯生物科技有限公司0755-83725681-603
上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
上海特伯化学科技有限公司+86-21-60341587 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
上海健超生物科技有限公司150-2103-5486 18017383231 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
上海贤鼎生物科技有限公司4009209199 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
深圳康特腾科技有限公司86-0755-86635001 · [email protected]
Related reactions
159 records
Compound notes
Loading…