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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 28310Generated: October 25, 2026

Ethyl 4-hydroxyphenylacetate

EPAN-003 · AKOS 90925 · ETHYL 4-HYDROXYPHENYLACETATE · 2-(4-hydroxyphenyl)butanoate · Ethyl (p-Hydroxyphenyl)acetate · Ethyl4-Hydroxyphenylacetate>ETHYL-4-HYDROXYPHENYLACETIC ACID · Ethyl 2-(p-Hydroxyphenyl)acetate · ETHYL 2-(4-HYDROXYPHENYL)ACETATE

https://huagongshe.com/en/chemical/28310

Ethyl 4-hydroxyphenylacetate molecular structure

Identifiers & Physical Properties

CAS No.17138-28-2
Molecular formulaC10H12O3
Average molar mass180.2 g/mol
Monoisotopic mass180.07864424 g/mol
SMILESCCOC(=O)Cc1ccc(O)cc1
InChIKeyHYUPPKVFCGIMDB-UHFFFAOYSA-N
PubChem CID28310
EC No.241-197-5
DTXSIDDTXSID0066165

Chemical & Physical Properties

XLogP1.9
Topological polar surface area46.5
Hydrogen bond donors1
Hydrogen bond acceptors3
Rotatable bonds4
Heavy atoms13
Formal charge0
Complexity160
Melting point36-38°C
Boiling point187-189°C 20mm
Density1.146±0.06 g/cm3(Predicted)
Refractive index1.52
Flash point187-189°C/20mm
Storage conditionsSealed in dry,Room Temperature
SolubilityChloroform
Physical stateBrown Semi-Solid
pKa (acidity coefficient)9.84±0.15(Predicted)
ColorWhite or Colorless to Light yellow
LogP (partition coefficient)1.760 (est)
CAS DataBase Reference17138-28-2(CAS DataBase Reference)
FDA UNII94NWB742CW
NIST Chemistry ReferenceBenzeneacetic acid, 4-hydroxy-, ethyl ester(17138-28-2)
EPA Substance Registry SystemBenzeneacetic acid, 4-hydroxy-, ethyl ester (17138-28-2)
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH315-H319
GHS precautionary statementsP264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety statements (S)22-24/25
TSCA inventory statusTSCA listed
Hazard classIRRITANT
Customs code2916340000

Safety & Regulations

GHS classificationThis chemical does not meet GHS hazard criteria for 25% (1 of 4) of reports.WarningH315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 4 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and CategoriesSkin Irrit. 2 (75%)
TSCA inventory statusTSCA listed
Customs code2916340000
Signal wordWarning
GHS pictogramGHS07
Safety statements (S)22-24/25
Hazard classIRRITANT
GHS hazard statementsH315-H319
GHS precautionary statementsP264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Applications & Uses

Uses

Ethyl 4-hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents.