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Methyltris(trimethylsiloxy)silane

HCID 28838
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Basic information

CAS
17928-28-8
Standard SMILES
C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C
InChIKey
RGMZNZABJYWAEC-UHFFFAOYSA-N
Molecular formula
C10H30O3Si4
Average molar mass
310.68 g/mol
Monoisotopic mass
310.12720095

Overview

Methyltris(trimethylsiloxy)silane is a clear colorless liquid. (NTP, 1992)

Names & identifiers

Preferred name
Methyltris(trimethylsiloxy)silane
IUPAC
trimethyl-[methyl-bis(trimethylsilyloxy)silyl]oxysilane
English name
Methyltris(trimethylsiloxy)silane
Molecular formula
C10H30O3Si4
Molecular weight
310.69

Names & synonyms

METHYLTRIS(TRIMETHYLSILOXY)SILANEMethyl trimethicone1,1,1,3,5,5,5-Heptamethyl-3-((trimethylsilyl)oxy)trisiloxanemethyl tris(trimethylsiloxy)silaneTrisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]-1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxaneUNII-S73ZQI0GXMS73ZQI0GXMEINECS 241-867-7Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-((trimethylsilyl)oxy)-tris(trimethylsiloxy)methylsilaneDTXSID9025669
Show more names
DK127Methyl tristrimethylsiloxyMultifunctional siloxane oligomer in water1,1,1,3,5,5,5-HEPTAMETHYL-3-HEXYLTRISILOXANEMethyltris(trimethylsiloxy)silane,17928-28-8Methyltris(trimethylsiloxy)silane in methanolrimethyl-[methyl-bis(trimethylsilyloxy)silyl]oxysilane
TMF-1.5EC 241-867-7Methyl tris-(trimethylsilyloxy)silaneRefChem:158355DTXCID105669METHYL TRIMETHICONE [INCI]RGMZNZABJYWAEC-UHFFFAOYSA-N17928-28-8

Properties

Computed structural properties

Topological polar surface area
27.7 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
3
Rotatable bonds
6
Heavy atoms
17
Formal charge
0
Complexity
209

Experimental & physicochemical properties

CosmeticsCosmetics ingredient -> Conditioning/Emollient; Solvent
SpringerMaterials PropertiesBoiling point
Density0.8536 at 68 °F (NTP, 1992) - Less dense than water; will float
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Flash Point187 °F (NTP, 1992)
Boiling Point381 °F at 760 mmHg (NTP, 1992)
Melting Point-105 °F (NTP, 1992)
Physical Description · 2 items

Methyltris(trimethylsiloxy)silane is a clear colorless liquid. (NTP, 1992)

Liquid

Physicochemical properties

Melting point
-76 °C · -76°C
Boiling point
60 °C · 60 °C

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 21.4% (41 of 192) of reports.

Warning

H226 (78.1%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 192 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 5 items

Chemical: Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]-

Hazard Traits - Bioaccumulation; Environmental Persistence

Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane (EC: 241-867-7)

Substance: 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane

DOT LabelCombustible Liquid
Fire HazardsThis chemical is combustible. (NTP, 1992)
Health HazardsExcerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
Reactive GroupSiloxanes

Chemistry & industry

Uses & manufacturing

U.S. Production2023: 75,000 - <500,000 lb
Consumer UsesDiluent
Household ProductsCosmetics product ingredient: 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane (Methyl trimethicone)
General Manufacturing InformationTrisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]-: ACTIVE

Applications

UsesMethyltris(trimethylsiloxy)silane was used in the study of thermal rearrangement of branched-chain methylpolysiloxanes.

General DescriptionClear colorless liquid.

Additional notes

DefinitionChEBI: Methyltris(trimethylsiloxy)silane is an organosilicon compound.

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes

Database identifiers

CAS
17928-28-8
PubChem CID
28838
DTXSID
DTXSID9025669
ChEBI
CHEBI:144342
UNII
S73ZQI0GXM
EC Number
241-867-7
Nikkaji
J260.797B
Density
0.849 · 0.849
vapor pressure
2.1 hPa · 2.1hPa at 25℃
refractive index
1.388 · 1.3880
Flash point
61 °C · 61°C
storage temp.
Store at room temperature, keep dry and cool
form
liquid
Specific Gravity
0.849 · 0.849
color
Colorless to Almost colorless
Viscosity
1.3 mm2/s · 1.3mm2/s
Water Solubility
0.1 g/100 · <0.1 g/100 mL at 20 ºC
Hydrolytic Sensitivity
1 · 1: no significant reaction with aqueous systems
Henry's Law Constant
2.9 · 2.9×10-8 mol/(m3Pa) at 25℃, Ebert et al. (2023)
Cosmetics Ingredients Functions
SKIN CONDITIONING - MISCELLANEOUSHAIR CONDITIONINGSOLVENT
LogP
8.2 at · 8.2 at 20℃
Substances of Very High Concern (SVHC) Candidate List
1 · 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane (17928-28-8)
CAS DataBase Reference
17928 · 17928-28-8(CAS DataBase Reference)
FDA UNII
73 ZQI0GXM · S73ZQI0GXM
NIST Chemistry Reference
1 · Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-(trimethylsiloxy)-(17928-28-8)
EPA Substance Registry System
1 · Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]- (17928-28-8)
Symbol(GHS)
7 · GHS07
Signal word
Warning
Hazard statements
315 · H315-H319-H227
Precautionary statements
501 · P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
Hazard Codes
Xi
Risk Statements
36 · 36/37/38-10
Safety Statements
26 · 26-36/37/39-36-16
RIDADR
1993 · 1993
TSCA
TSCA listed
HS Code
2931.9 · 2931.90.9010
REACH Registrations
Active
Air and Water Reactions
Insoluble in water.
Hazard Classes and CategoriesFlam. Liq. 3 (78.1%)

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Safety data

tsca
TSCA listed
ridadr
1993
hs_code
2931.90.9010
risk_code
36/37/38-10
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xi
safety_code
26-36/37/39-36-16
Hazard statements
H315-H319-H227
REACH Registrations
Active
Precautionary statements
P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235