Basic information
- CAS
77-39-4- Standard SMILES
OC(CCN1CCCCC1)(c1ccccc1)C1CCCC1- InChIKey
SWRUZBWLEWHWRI-UHFFFAOYSA-N- Molecular formula
- C19H29NO
- Average molar mass
- 287.4 g/mol
- Monoisotopic mass
- 287.22491455
Overview
Cycrimine is a member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a member of piperidines, a tertiary alcohol and a tertiary amino compound.
Names & identifiers
- Preferred name
- Cycrimine
- IUPAC
- 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
- English name
- cycrimine
- Molecular formula
- C19H29NO
- Molecular weight
- 287.444
Names & synonyms
cycrimine77-39-4CicriminaCycriminum(+-)-cycrimine1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-olalpha-Cyclopentyl-alpha-phenyl-1-Piperidinepropanol543567RFQQCHEBI:59692DTXSID508617691-Piperidinepropanol, alpha-cyclopentyl-alpha-phenyl-RefChem:130055
Show more names
cycrimine USP/EP/BP1-Piperidinepropanol, α-cyclopentyl-α-phenyl-α-Cyclopentyl-α-phenyl-1-piperidine-1-propanol1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
DTXCID50810651alpha-cyclopentyl-alpha-phenyl-1-piperidinepropanol.HCl201-024-61-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol1-Piperidinepropanol, a-cyclopentyl-a-phenyl-1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-.alpha.-Cyclopentyl-.alpha.-phenyl-1-piperidinepropanolCycriminum [INN-Latin]
Database identifiers
- CAS
77-39-4
Properties
Computed structural properties
- XLogP
- 3.9
- Topological polar surface area
- 23.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 5
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 301
Experimental & physicochemical properties
LogP4
Solubility9.09e-03 g/L
Melting Point112-113
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 90 · 90-92°C
- Boiling point
- 125 · 125-135 °C(Press: 0.02 Torr)
- Density
- 1.057 · 1.057±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly)
- form
- Solid
- pka
- 14.4 · 14.40±0.29(Predicted)
- color
- Off-White to Pale Yellow
- Stability
- Stable under recommended storage conditions., Stable Under Recommended Storage C
Chemistry & industry
Pharmacology
Protein Binding14-21%
Pharmacodynamics
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Mechanism of ActionCycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.
Cellular LocationsMembrane
Applications
UsesCycrimine is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
Upstream & downstream products
Upstream raw materials
Suppliers10 total
北京华美互利生物化工010-56205725 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
北京百奥创新科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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