Basic information
- CAS
83373-60-8- Standard SMILES
S=C(S)OC1CC2CC1C1CCCC21- InChIKey
PWLXJBSAUKKGCM-UHFFFAOYSA-N- Molecular formula
- C11H16OS2
- Average molar mass
- 228.4 g/mol
- Monoisotopic mass
- 228.06425748
Overview
LSM-5150 is a monoterpenoid.
Names & identifiers
- Preferred name
- Tricyclo-decan-9-yl-xanthogenate (racemate)
- IUPAC
- 8-tricyclo[5.2.1.02,6]decanyloxymethanedithioic acid
- English name
- D609
- Molecular formula
- C11H17KOS2
- Molecular weight
- 268.47
Names & synonyms
Tricyclo-decan-9-yl-xanthogenate (racemate)CHEMBL116189483373-60-88-Tricyclo[5.2.1.02,6]decanyloxymethanedithioic acidD609CBiol_001959O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate Potassium salt[?]yloxymethanedithioic acidLopac0_001242KBioGR_000323KBioSS_000323SCHEMBL1535769
Show more names
D609 ,98%D609,D-609D-609 POTASSIUMD609 POTASSIUM SALTD609, 10 mM in DMSOD609 potassium salt,98%Tricyclodecan-9-yl xanthateTricyclodecan-9-yl xanthogenatetricyclodecane-9-yl-xanthogenate
BCBcMAP01_000222CHEBI:94441KBio2_000323KBio2_002891KBio2_005459KBio3_000645KBio3_000646Bio1_000245
Database identifiers
- CAS
83373-60-8- PubChem CID
- 2941
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 42.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 266
Physicochemical properties
- storage temp.
- 0 · 0-6°C
- solubility
- 2 O: · H2O: 300 mg/mL
- form
- solid
- color
- off-white
- biological source
- synthetic (organic)
- Water Solubility
- 100 mM · Soluble to 100 mM in water
- InChI
- 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7,8,9-,10;/m1./s1
- InChIKey
- IGULCCCBGBDZKQ-HJPGVBIPSA-M
- SMILES
- [K]SC(=S)OC1CC2CC1C3CCCC23
- FDA UNII
- 5 QC1Z07M77 · 5QC1Z07M77
- UNSPSC Code
- 41106500 · 41106500
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 264 · P264-P270-P301+P312-P330-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- hs_code
- 29333990
- risk_code
- 22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Applications
DescriptionD609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
UsesD609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.
Suppliers49 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Related reactions
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Compound notes
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