Basic information
- CAS
19216-53-6- Standard SMILES
COc1cc2nc(N(C)C)nc(N)c2cc1OC- InChIKey
JALPLGVFZRCLGE-UHFFFAOYSA-N- Molecular formula
- C12H16N4O2
- Average molar mass
- 248.28 g/mol
- Monoisotopic mass
- 248.12732577
Names & identifiers
- Preferred name
- 2,4-Quinazolinediamine, 6,7-dimethoxy-N2,N2-dimethyl-
- IUPAC
- 6,7-dimethoxy-2-N,2-N-dimethylquinazoline-2,4-diamine
- English name
- Alfuzosin
- Molecular formula
- C12H16N4O2
- Molecular weight
- 248.28
Names & synonyms
19216-53-6N2VRC6C8HUUNII-N2VRC6C8HU6,7-Dimethoxy-N2,N2-dimethyl-2,4-quinazolinediamineNSC 403405NSC-4034052,4-Quinazolinediamine, 6,7-dimethoxy-N2,N2-dimethyl-Alfuzosin hydrochloride impurity F [EP]ALFUZOSIN HYDROCHLORIDE IMPURITY F [EP IMPURITY]ALFUZOSIN HYDROCHLORIDE IMPURITY F (EP IMPURITY)RefChem:197392Alfuzosin hydrochloride impurity F
Show more names
Alfuzosin Impurity 6Alfuzosin EP Impurity FAlfuzosin EP Impurity F 6,7-dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine
6,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine6,7-dimethoxy-2-N,2-N-dimethylquinazoline-2,4-diamineMLS000047893SMR0000338934-amino-2-dimethylamino-6,7-dimethoxyquinazoline6,7-dimethoxy-N~2~,N~2~-dimethylquinazoline-2,4-diamineAlfuzosin Impurity FChemDiv2_004346
Database identifiers
- CAS
19216-53-6- PubChem CID
- 29503
- DTXSID
DTXSID001384154
Properties
Computed structural properties
- XLogP
- 1.7
- Topological polar surface area
- 73.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 277
Physicochemical properties
- Boiling point
- 437.4 · 437.4±55.0 °C(Predicted)
- Density
- 1.252 · 1.252±0.06 g/cm3(Predicted)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.06 · 8.06±0.70(Predicted)
- color
- White to Off-White
- FDA UNII
- 2 VRC6C8HU · N2VRC6C8HU
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 335 · H335-H315-H319
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (66.7%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H335-H315-H319
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Applications
Uses6,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine is an impurity of Alfuzosin (A532000), which is α1-adrenoceptor antagonist structurally similar to Prozosin. Alfuzosin is antihypertensive and is used in treatment of benign prostatic hypertrophy. Alfuzosin EP Impurity F
Suppliers14 total
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
孟成科技（上海）有限公司400-820-6829 · [email protected]
上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]
TLC梯尔希（南京）药物研发有限公司18012923235 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
河南誉康卓宁进出口有限公司13393721940 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
sgtlifesciences pvt ltd+91-8790379245 · [email protected]
陕西缔都医药化工有限公司029-81154043 17391733319 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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