Azoxystrobin

Use dry chemical, foam or CO2 extinguishing media. Wear full protective clothing and self-contained breathing apparatus. Evacuate nonessential personnel from the area to prevent human exposure to fire, smoke, fumes or products of combustion. Prevent use of contaminated buildings, area, and equipment until decontaminated. Water runoff can cause environmental damage. If water is used to fight fire, dike and collect runoff.

Store commercial products in a well-ventilated, secure area out of the reach of children and domestic animals. Do not store food, beverages or tabacco in the storage area.

Store in original containers only. Keep container closed when not in use. Do not store near food or feed. /Abound Flowable Fungicide/

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential users/

In case of spill on floor or paved surfaces, mop and remove to chemical waste storage area until proper disposal can be made if product cannot be used according to the label. /Abound Flowable Fungicide/

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential users/

After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential users/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Dispose of product containers, waste containers, and residues according to local, state, and federal health and environmental regulations.

Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential users/

Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Many communities have programs to recycle household waste such as empty bottles and cans. Do not recycle any pesticide containers, however, unless the recycling program specifically accepts pesticide containers and you follow the program's instructions for preparing the empty containers for collection. /Residential users/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. /Abound Flowable Fungicide/

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. /Abound Flowable Fungicide/

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 4 hours. /Abound Flowable Fungicide/

For more Preventive Measures (Complete) data for AZOXYSTROBIN (12 total), please visit the HSDB record page.

Tolerances are established for residues of the fungicide, azoxystrobin, including its metabolites and degradates, in or on the commodities in the following table. Compliance with the tolerance levels specified in the table is to be determined by measuring only the sum of azoxystrobin, [methyl(E)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate], and the Z-isomer of azoxystrobin [methyl(Z)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3methoxyacrylate] in or on the commodity. [Table#6622]

Tolerances are established for residues of the fungicide, azoxystrobin, including its metabolites and degradates, in or on the commodities in the following table. Compliance with the tolerance levels specified in the table is to be determined by measuring only the sum of azoxystrobin, [methyl(E)-2-(2-(6-(2-cyanophenoxy) pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate], and the Z-isomer of azoxystrobin [methyl(Z)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3 methoxyacrylate] in or on the commodity. [Table#6623]

Personal Protective Equipment (PPE) ... Applicators and other handlers must wear: Long-sleeved shirt and long pants; Chemical resistant gloves made of any waterproof material such as polyvinyl chloride, nitrile rubber or butyl rubber; Shoes plus socks. /Abound Flowable Fungicide/

Chemical-resistant gloves. Long-sleeved shirt and long pants. Shoes plus socks.

LD50; Species: Colinus virginianus (Bobwhite) oral >2000 mg/kg /Conditions of bioassay not specified./

LC50; Species: Colinus virginianus (Bobwhite) oral >5200 ppm /Conditions of bioassay not specified./

LD50; Species: Anas platyrhynchos (Mallard) oral >250 mg/kg

LC50; Species: Anas platyrhynchos (Mallard) oral >5200 mg/kg

For more Ecotoxicity Values (Complete) data for AZOXYSTROBIN (22 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), reported Koc values of 207 to 594(2) indicate that azoxystrobin is expected to have moderate to low mobility in soil(SRC). Volatilization of azoxystrobin from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.3X10-14 atm-cu m/mole(SRC), based upon its vapor pressure, 8.25X10-13 mm Hg(3), and water solubility, 6 mg/L(3). Azoxystrobin is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Azoxystrobin was present at 22.3 and 60.9% of applied dose (100 mg/kg) to compost aged for 3 and 12 months, respectively, in 125-day tests(2), suggesting that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), reported Koc values of 207 to 594(2) indicate that azoxystrobin is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 7.3X10-14 atm-cu m/mole(SRC), derived from its vapor pressure, 8.25X10-13 mm Hg(4), and water solubility, 6 mg/L(4). According to a classification scheme(5), an estimated BCF of 21(SRC), from its log Kow of 2.50(4) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Azoxystrobin, in aqueous solution absorbs light at wavelengths of >290 nm and can be photodegraded, ten photo products have been tentatively identified(7). In the dark and under aerobic conditions, the half-life of azoxystrobin was in the range of eight to 12 weeks and the major metabolite formed upon degradation resulted from the hydrolysis of the ester moiety(7). Azoxystrobin has been experimentally shown to be stable to hydrolysis at pH 5 and 7, at pH 9 a half-life of 12.1 days is reported(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), azoxystrobin, which has a vapor pressure of 8.3X10-13 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase azoxystrobin may be removed from the air by wet or dry deposition(SRC).

Azoxystrobin residue in fresh grapes was 0.63 to 1.76 mg/kg, in washed grapes was 0.11 to 0.25 mg/g, in sun dried grapes (raisins) 1.68 to 2.08 mg/kg and in alkali washed sun dried grapes 0.51 to 1.49 mg/kg(1). Of 173 agricultural products analyzed in 2006 in Japan, eight were reported to contain azoxystrobin at 5.4-77.9 ng/g(2).

Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97)

/AQUATIC SPECIES/ ...The acute and chronic physiological effects of the strobilurin fungicide azoxystrobin on three clones of D. magna originating from different Danish lakes were evaluated. Significant clonal variation in the sensitivity of D. magna toward azoxystrobin was demonstrated. One clone had a 48 hr median lethal concentration (LC50) of 0.277 mg/L (95% confidence limits (CL), 0.145 and 0.427 mg/L), which is comparable to the value widely used in risk assessments (0.259 mg/L). The two remaining clones were far more sensitive, however, and had LC50s of 0.071 mg/L (95% CL, 0.034 and 0.126 mg/L) and 0.098 mg/L (95% CL, 0.066 and 0.139 mg/L), respectively. Furthermore, through respiration measurements and life-table experiments, sublethal stress was shown to exist at exposure to an ecologically relevant concentration (0.026 ug/L). Based on these results, we may expect changes in daphnid populations at azoxystrobin concentrations much lower than previously thought.

/AQUATIC SPECIES/ Atlantic salmon smolts were exposed to three doses of the fungicide azoxystrobin for 4 days, and physiological blood parameters and transcriptional effects in liver and muscle were evaluated in search for potential negative effects. Azoxystrobin exposure mediated up-regulation of catalase, MAPK1 /mitogen-activated protein kinase 1/ and IGFBP1 /insuline-like growth factor binding protein 1/ in liver tissue. Catalase, transferrin, IGFBP1 and TNFR /tumor necrosis factor receptor/ were up-regulated and CYP1A /cytochrome p450 1A/ down-regulated in muscle tissue. Blood parameters glucose, hematocrit, pCO(2), HCO(3) and pH grouped together with transcripts levels of MnSOD, MAPK1, IGFBP1, MAP3K7 /mitogen-activated protein kinase kinase kinase 7/ and GPx4 in liver of fish exposed to the highest azoxystrobin concentration (352 ug/L) using principal component analysis (PCA). In muscle, the blood parameters glucose, hematocrit, pCO(2), HCO(3) and pH grouped together with transcript levels of heme oxygenase, thioredoxin, MnSOD, TNFR and MMP9.

/AQUATIC SPECIES/ ...In this study... the joint effect of the imidazole fungicide prochloraz together with the herbicides acifluorfen, diquat and terbuthylazine, the fungicide azoxystrobin and the insecticides chlorfenvinphos, dimethoate, and pirimicarb on the bacteria Vibrio fischeri (six binary mixtures), the crustacean Daphnia magna (four binary mixtures), the algae Pseudokirchneriella subcapitata (four binary mixtures) and the floating plant Lemna minor (three binary mixtures) /was tested/. All the binary mixtures were evaluated both in relation to the model of concentration addition and independent action using isobolograms. The study showed strong synergy in relation to concentration addition between prochloraz and azoxystrobin, diquat and esfenvalerate on D. magna with sums of toxic units for the 50:50% effect mixture (summation TU(50:50)) as low as 0.25. The mixture with dimethoate was however antagonistic with summation TU(50:50) of 2.04. Four out of the six mixtures tested on V. fisheri showed synergy in relation to concentration addition, but for three of the mixtures the response could be explained by independent action. ... There was no significant synergy for any of the combinations tested on the plant and the algae species in relation to concentration addition and only for diquat in the algae-test in relation to independent action. Hence, prochloraz does synergise the effect of some pesticides in the aquatic environment, but not consistently across species. The organism most susceptible to synergy by prochloraz in this study was D. magna. Especially the combination with insecticides such as esfenvalerate, where the concentration needed to immobilize 50% of the daphnia was reduced from >3 ug/L to less than 0.5 ug/L when prochloraz was added, could be problematic as these concentrations are environmentally realistic.

The Koc of azoxystrobin has been reported to range from 207 to 594(1). According to a classification scheme(2), this Koc range suggests that azoxystrobin is expected to have moderate to low mobility in soil(SRC). Using a constructed biobed, which is an excavation lined with clay and filled with a mixture of shopped straw, sphagnum and soil with turf on top, it was observed that azoxystrobin concentration in leachate from day zero to day 563 was always <0.5 ug/L(3).

SOURCE DOMINATED: Average daily ambient azoxystrobin concentrations were 1.2X10-10, 2.1X10-10 and 1.5X10-10 ug/cu m over golf courses in Boston, MA, Philadelphia, PA and Rochester, NY, respectively(1). Maximum concentrations of azoxystrobin over the same golf courses were 2.3X10-9, 3.9X10-9 and 2.9X10-9 ug/cu m, respectively(1).

/GENOTOXICITY/ In vitro chromosome aberrations in human lymphocytes assay: The test was positive for the induction of chromosomal aberrations in both the presence and absence of S9 activation at doses (5-50 ug/mL +S9) that were moderately to severely cytotoxic (ie, > or = 16-70% reductions in mitotic cells, respectively).

AEROBIC: In the dark and under aerobic conditions, the half-life of azoxystrobin was in the range of 8 to 12 weeks and the major metabolite formed upon degradation resulted from the hydrolysis of the ester moiety(1). Azoxystrobin was present at 22.3 and 60.9% of applied dose (100 mg/kg) to compost aged for 3 and 12 months, respectively, in 125-day tests; first-order kinetic degradation half-lives of 116 and 353 days, respectively, were calculated. The compost was a mixture of urban waste and garden compost from a compost production plant in Pietramelina, Perugia, Italy(2).

Regulation (EC) No 396/2005 (amended)

Azoxystrobin is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)

1998/47/EC, 2007/21/EC, 2010/55/EU, Reg. (EU) 2018/155, Reg. (EU) 2024/2781, Reg. (EU) No 2019/291, Reg. (EU) No 540/2011, Reg. (EU) No 703/2011

Azoxystrobin: HSNO Approval: HSR100142 Approved with controls

Tolerances are established for residues of the fungicide, azoxystrobin, including its metabolites and degradates, in or on the commodities in the following table. Compliance with the tolerance levels specified in the table is to be determined by measuring only the sum of azoxystrobin, [methyl(E)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate], and the Z-isomer of azoxystrobin [methyl(Z)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3methoxyacrylate] in or on the commodity. [Table#6624]

Tolerances are established for residues of the fungicide, azoxystrobin, including its metabolites and degradates, in or on the commodities in the following table. Compliance with the tolerance levels specified in the table is to be determined by measuring only the sum of azoxystrobin, [methyl(E)-2-(2-(6-(2-cyanophenoxy) pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate], and the Z-isomer of azoxystrobin [methyl(Z)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3 methoxyacrylate] in or on the commodity. [Table#6625]

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 128810; Type of Pesticide: fungicide; Use Site: food and non-food use; Year: 1997.

Used as an agricultural fungicide; [Merck Index] Used as a fungicide on golf courses and turf farms; [Reference #1]

Farming (Pesticides) [Category: Industry]

For azoxystrobin (USEPA/OPP Pesticide Code: 128810) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Agricultural fungicide

This is a man-made compound that is used as a pesticide.

Wettable granule, flowable, suspension concentrate.

Premix Partners: Chlorothalonil; Cyproconazole, Difenoconazole; Fenpropimorph; Fludioxonil; Metalaxyl-M; Propiconazole; Spinosad; Thiabendazole; Thiamethoxam.

Heritage Fungicide (Syngenta Crop Protection, LLC): Azoxystrobin 50%.

Abound Flowable Fungicide (Syngenta Crop Protection, LLC): Azoxystrobin 22.9%.

For more Formulations/Preparations (Complete) data for AZOXYSTROBIN (51 total), please visit the HSDB record page.

Pesticides -> Fungicides -> Antibiotic fungicides -> Strobilurin fungicides

Fungicides

Environmental transformation -> Pesticides (parent, predecessor)