Basic information
- CAS
67810-56-4- Standard SMILES
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O- InChIKey
YQEWLSJJOSZFHG-DSFKZNPVSA-N- Molecular formula
- C74H122N18O25S
- Average molar mass
- 1,695.9 g/mol
Names & identifiers
- Preferred name
- gamma-endorphin, des-Tyr(1)-
- IUPAC
- (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid
- English name
- GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU
- Molecular formula
- C74H122N18O25S
- Molecular weight
- 1695.93
Names & synonyms
Dtgammae67810-56-4(Des-tyr(1))-gamma-endorphinbeta-Lph(62-77)1-De-tyr-gamma-endorphinbeta-Lipotropin(62-77)gamma-Endorphin, des-tyr(1)-gamma-Endorphin, des-tyrosine(1)-RefChem:142297[Des-Tyr1]-gamma-Endorphin[Des-Tyr1] g-Endorphin1-De-L-tyrosine-16a-L-leucine-alpha-endorphin (sheep)
Show more names
β-lipotropin 62-77des-tyr1-γ-endorphinBETA-ENDORPHIN (2-17)BETA-LIPOTROPIN (62-77)DES-TYR1-GAMMA-ENDORPHINdes-tyr(1)-gamma-endorphi2-16-α-Endorphin (sheep), 16a-L-leucine-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU
orb2645914alpha-Endorphin (sheep), 1-de-L-tyrosine-16a-L-leucineYQEWLSJJOSZFHG-DSFKZNPVSA-NHY-P10498TP2751CS-1102343H-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OH
Properties
Computed structural properties
- XLogP
- -9.6
- Topological polar surface area
- 724 Ų
- Hydrogen bond donors
- 24
- Hydrogen bond acceptors
- 28
- Rotatable bonds
- 55
- Heavy atoms
- 118
- Formal charge
- 0
- Complexity
- 3,390
Physicochemical properties
- RTECS
- 2250000 · JZ2250000
- storage temp.
- 20 °C · −20°C
- form
- Solid
- Sequence
- Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu
- WGK Germany
- 3 · 3
Safety & regulation
Safety data
- wgk
- 3
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Applications
Uses[Des-Tyr1]-gamma-Endorphin is a neuropeptide, which can be found in human cerebrospinal fluid. [Des-Tyr1]-gamma-Endorphin exhibits antidepressant efficacy, facilitates the extinction of active avoidance and attenuates the passive avoidance behavior in rats[1].
Suppliers26 total
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
太原百利恒康生物技术有限公司19135651983 · [email protected]
Moxin Chemicals+86-17320513646 +86-17320513646 · [email protected]
康明永瑞生物科技（苏州）有限公司
Related reactions
2 records
Compound notes
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