Diisopropyl phosphite

HCID 3072CAS 1809-20-7
Substructure searchFind similar structures

Basic information

Standard SMILES
CC(C)O[PH](=O)OC(C)C
InChIKey
BLKXLEPPVDUHBY-UHFFFAOYSA-N
Molecular formula
C6H15O3P
Average molar mass
166.16 g/mol
Monoisotopic mass
166.07588133

Names & identifiers

Preferred name
Diisopropyl phosphite
IUPAC
2-propan-2-yloxyphosphonoyloxypropane
English name
Diisopropyl phosphite
Molecular formula
C6H15O3P
Molecular weight
166.16

Names & synonyms

RefChem:920277217-317-71809-20-7676G4RQ6NDbis(propan-2-yl) phosphonateDiisopropyl hydrogen phosphiteDiisopropyl hydrogen phosphonateDiisopropyl phosphiteDiisopropyl phosphonateDiisopropylphosphonateIsopropyl phosphonateNSC-82344
Show more names
Diisopropylphosphine oxide3P-230(iPrO)2P(O)HO,O-DiisopropyLisopropylphosphonateDI-I-PROPYLPHOSPHITEDiisopropyl phosphit
O,O-diisopropyl phosphitePhosphonic acid, bis(1-methylethyl) esterPhosphonic acid, diisopropyl ester

Database identifiers

CAS
1809-20-7
PubChem CID
3072
DTXSID
DTXSID7061988
EC Number
217-317-7

Properties

Computed structural properties

XLogP
0.4
Topological polar surface area
35.5 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
3
Rotatable bonds
4
Heavy atoms
10

Experimental & physicochemical properties

Vapor Pressure0.54 [mmHg]
Physical DescriptionLiquid; [Alfa Aesar MSDS]

Physicochemical properties

Boiling point
71 °C · 71 °C (8 mmHg)
Density
0.997 · 0.997
refractive index
1.4065 · 1.4065-1.4085
Flash point
69 °C · 69°C
storage temp.
Inert atmosphere,Room Temperature
solubility
Chloroform (Sparingly), Methanol (Sparingly)

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 78.2% (43 of 55) of all reports.

Warning

H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (18.2%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (20%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (16.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 55 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 43 of 55 reports by companies.；There are 9 notifications provided by 12 of 55 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 2 items

Chemical: Phosphonic acid, bis(1-methylethyl) ester

Phosphonic acid, bis(1-methylethyl) ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards Summary · 1 item

Causes convulsions and lung changes in inhalation lethal-concentration studies of rats, mice, and guinea pigs; [RTECS] A skin and strong eye irritant; Harmful by inhalation; Toxic by ingestion; [Alfa Aesar MSDS] See Dimethyl hydrogen phosphite.

Hazard Classes and CategoriesAcute Tox. 4 (20%)；Skin Irrit. 2 (18.2%)；Eye Irrit. 2A (20%)；STOT SE 3 (16.4%)

Toxicology

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Toxicity DataLC50 (rat) = 9,600 mg/m3

Regulatory information

Regulatory Information · 2 items

Chemical: Phosphonic acid, bis(1-methylethyl) ester

Phosphonic acid, bis(1-methylethyl) ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Safety data

tsca
TSCA listed
rtecs
SZ7660000
ridadr
3265
hs_code
29209085
Toxicity
guinea pig,LC50,inhalation,9010mg/m3 (9010mg/m3),LUNGS, THORAX, OR RESPIRATION: OTHER CHANGESGASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 29(11), Pg. 51, 1985.
risk_code
36/37/38-22

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPhosphonic acid, bis(1-methylethyl) ester: ACTIVE

Applications

UsesDiisopropyl phosphite is used as antiwear lubricant additive together with triphenyl thiophosphate on T8 steel/Al2O3 ceramics.

Preparation methods · 1 item

PreparationDiisopropyl phosphite is prepared by directly reacting isopropanol with phosphorus trichloride.3(CH3)2CHOH+PCl3→[(CH3)2CHO]2POH+2HCl↑+(CH3)2CHClAt a ratio of 3:1 (mol), continuously feed 215kg/h of isopropanol and 150kg/h of phosphorus trichloride. When mixed, this results in a violent reaction that generates hydrogen chloride gas. This gas is quickly removed from the mixing pot using vacuum mercury. The crude ester produced is then heated in a falling film type spinner deacidification device and further deacidified. The resulting product is then cooled to below 40°C and obtained with a content of 92%-95% and a yield of 95%～98%.

Upstream & downstream products

Suppliers50 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南京一化生物科技有限公司13429882898; 13429882898
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

Related reactions

41 records
New reaction record

Linked notes

Loading…