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Basic information
- CAS
1140-81-4- Standard SMILES
CC(=O)Nc1ccc2[nH]c(C)cc(=O)c2c1- InChIKey
INGXYDNOMOPBLY-UHFFFAOYSA-N- Molecular formula
- C12H12N2O2
- Average molar mass
- 216.24 g/mol
- Monoisotopic mass
- 216.08987762
Names & identifiers
- Preferred name
- N-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
- IUPAC
- N-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
- English name
- 6-Acetamido-4-hydroxy-2-methylquinoline
- Molecular formula
- C12H12N2O2
- Molecular weight
- 216.24
Names & synonyms
6-Acetamido-4-hydroxy-2-methylquinoline6-Acetamido-2-methyl-4-hydroxyquinolineN-Acetyl-4-hydroxy-2-methyl-6-quinolinamineN-(4-Hydroxy-2-methyl-6-quinolinyl)acetamideN-(2-methyl-4-oxo-1H-quinolin-6-yl)acetamideN-(4-hydroxy-2-Methylquinolin-6-yl)acetaMideAcetamide, N-(4-hydroxy-2-methyl-6-quinolinyl)-n-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
Database identifiers
- CAS
1140-81-4、501653-43-6- PubChem CID
- 308136
- DTXSID
DTXSID901220004- ChEMBL
CHEMBL1487772- EC Number
- 664-220-4
Properties
Physicochemical properties
- Melting point
- 300 °C · >300 °C
- Boiling point
- 496 · 496.0±40.0 °C(Predicted)
- Density
- 1.314 · 1.314±0.06 g/cm3(Predicted)
- solubility
- Ethyl Acetate; Toluene
- pka
- 4.29 · 4.29±0.40(Predicted)
- form
- Solid
- color
- Yellow
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H319
- Precautionary statements
- 264 · P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H319
- Precautionary statements
- P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Chemistry & industry
Applications
UsesN-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
Upstream & downstream products
Upstream raw materials
Suppliers11 total
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
上海技毅生物科技有限公司13621943973 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
上海凯裕医药科技有限公司17317130613 · [email protected]
重庆卡兰医药有限公司[email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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