2-Methylpentaldehyde

Other Classes -> Aldehydes

Flammable agents - 3rd degree

0.8092

0.805-0.811

Sol in water, ether, acetone, slightly sol in carbon tetrachloride.

Water solubility = 0.42% wt at 25 °C

4.2 mg/mL at 25 °C

(in ethanol)

68 °F (NFPA, 2010)

20 °C

68 °F (20 °C) (OPEN CUP)

117 °C

116 °C

Danger

H225 (16.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P264, P264+P265, P273, P280, P302+P352, P303+P361+P353, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1548 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

Chemical: Pentanal, 2-methyl-

Status: Active Update: 26-05-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/12255

Pentanal, 2-methyl-: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

· May cause toxic effects if inhaled or absorbed through skin.

· May cause toxic effects if inhaled or absorbed through skin.

2367 130

2367 130

ALPHA-METHYLVALERALDEHYDE is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for 2-METHYLPENTALDEHYDE (8 total), please visit the HSDB record page.

alpha-Methylvaleraldehyde

UN2367

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

PG II: the degree of danger presented by the material is medium

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

Immediate precautionary measure

Immediate precautionary measure

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 44(SRC), determined from an experimental water solubility of 4200 mg/L at 25 °C(2) and a recommended regression-derived equation(3), indicates that 2-methylpentaldehyde will have very high mobility in soil(SRC). Volatilization of 2-methylpentaldehyde may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.7X10-4 atm-cu m/mole(4,SRC), and from dry soil surfaces(SRC) based on an estimated vapor pressure of 18 mm Hg(5,SRC). Insufficient data are available to determine the rate or importance of biodegradation of 2-methylpentaldehyde in soil(SRC), but simple aldehydes are generally biodegradable(6).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 44(SRC), determined from an experimental water solubility of 4200 mg/L at 25 °C(2) and a recommended regression-derived equation(3), indicates that 2-methylpentaldehyde may not adsorb to suspended solids and sediment(SRC) in the water. 2-Methylpentaldehyde may volatilize from water surfaces based on an estimated Henry's Law constant of 3.7X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 5.3 hours and 4.7 days, respectively(3,SRC). An estimated BCF value of 5.6(3,SRC), from an experimental water solubility(2), suggests that 2-methylpentaldehyde will not bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(5). Insufficient data are available to determine the rate or importance of biodegradation of 2-methylpentaldehyde in water(SRC), but simple aldehydes are genrally biodegradable(6).

ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 18 mm Hg at 25 °C(2,SRC) indicates that 2-methylpentaldehyde will exist in the vapor phase in the ambient atmosphere. Vapor-phase 2-methylpentaldehyde is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 13 hours(3,SRC).

The Koc of 2-methylpentaldehyde is estimated as approximately 44(SRC), using an experimental water solubility of 4200 mg/L at 25 °C(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 2-methylpentaldehyde has very high mobility in soil(SRC).

PRIMARY IRRITATION OF SKIN, EYES, & MUCOSA OF THE RESPIRATORY TRACT. ... SENSITIZATION...KNOWN TO OCCUR ON CONTACT WITH...VARIOUS /ALDEHYDES/. /ALDEHYDES/

STRONG IRRITANT TO SKIN & MUCOUS MEMBRANES.

The mucus membranes of the nasal and oral passages and the upper respiratory tract are affected, producing a burning sensation ... bronchial constriction, choking, and coughing. The eyes tear, and a burning sensation is noted on the skin of the face. /Aldehydes/

An estimated BCF value of 5.6 was calculated for 2-methylpentaldehyde(SRC), using an experimental water solubility of 4200 mg/L at 25 °C(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process(SRC).

The Henry's Law constant for 2-methylpentaldehyde is estimated as 3.7X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2-methylpentaldehyde will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 5.3 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 4.7 days(2,SRC). 2-Methylpentaldehyde's vapor pressure, 17.9 mm Hg(3,SRC) and Henry's Law constant(1,SRC) indicate that volatilization from dry and moist soil may occur(SRC).

The rate constant for the vapor-phase reaction of 2-methylpentaldehyde with photochemically produced hydroxyl radicals has been estimated as 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 13 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

The general population can be exposed to 2-methylpentaldehyde in foodstuffs based on its natural existence as a volatile component in onion, garlic, milk, meat, and roasted peanuts(1), its use as a flavoring ingredient(1), and through ingestion, inhalation, and dermal contact(SRC). Occupational exposure to aldehydes, such as 2-methylpentaldehyde(SRC), can occur through dermal contact, inhalation, and ingestion(2).

2-Methylpentaldehyde's production and use as a flavoring ingredient and an intermediate for dyes, resins, and pharmaceuticals may result in its release to the environment through various waste streams. 2-Methylpentaldehyde is a volatile component in onion, garlic, milk, meat, and roasted peanuts. 2-Methylpentaldehyde has also been found in sea water near Denmark. If released to soil, 2-methylpentaldehyde will have very high mobility. Volatilization of 2-methylpentaldehyde may be important from moist and dry soil surfaces. Insufficient experimetnal data are available to determine the rate or importance of biodegradation of 2-methylpentaldehyde in soil or water, but simple aldehydes are generally biodegradable. If released to water, 2-methylpentaldehyde may not adsorb to suspended solids and sediment. 2-Methylpentaldehyde may volatilize from water surfaces with estimated half-lives for a model river and model lake of 5.3 hours and 4.7 days, respectively. An estimated BCF value of 5.6, suggests that 2-methylpentaldehyde will not bioconcentrate in aquatic organisms. If released to the atmosphere, 2-methylpentaldehyde will exist in the vapor phase. Vapor-phase 2-methylpentaldehyde is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of about 13 hours. The general population can be exposed to 2-methylpentaldehyde in foodstuffs based on its natural existence as a volatile component in onion, garlic, milk, meat, and roasted peanuts, its use as a flavoring ingredient, and through ingestion, inhalation, and dermal contact. (SRC)

Aldehydes are readily oxidized to organic acids, which, in turn, can serve as substrates for fatty acid oxidation pathways and the Krebs cycle. ... Oxidation of aldehydes is catalyzed by aldehyde dehydrogenase, which has been found in the brain, erythrocytes, liver, kidney, heart, and placenta. /Aldehydes/

... The detoxification of aldehydes can be seen to proceed basically via two routes: (1) an oxidation to yield readily metabolized acids; (2) inactivation by reaction with sulfhydryl groups, particularly glutathione. Under conditions that either deplete glutathione levels, or that result in an inhibition of aldehyde dehydrogenase (for example, Antabuse treatment), the acute and chronic effects of aldehyde toxicity might be more fully expressed. /Aldehydes/

Used as a food flavor, intermediate (dyes, resins, and pharmaceuticals), and insect sex attractant; [HSDB] Used in rubber manufacturing; [CAMEO]

FLAVORING INGREDIENT

INTERMEDIATE FOR DYES, RESINS, PHARMACEUTICALS

USED AS INSECT SEX ATTRACTANT

FROM 2-METHYLPENTANOL BY CATALYTIC OXIDATION.

By aldol condensation of propanal.

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Pentanal, 2-methyl-: ACTIVE

NON-ALCOHOLIC BEVERAGES 2.0 PPM; ICE CREAM, ICES, ETC 2.0 PPM; CANDY 2.0 PPM; BAKED GOODS 2.0 PPM; GELATINS & PUDDINGS 2.0 PPM; CHEWING GUM 2.0 PPM.

FLAVOR USEFUL IN HAM.