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Basic information
- CAS
113104-25-9- Standard SMILES
O=[N+]([O-])c1ccc(Sc2cccc[n+]2[O-])c2nonc12- InChIKey
ICCFXXDUYSPKOL-UHFFFAOYSA-N- Molecular formula
- C11H6N4O4S
- Average molar mass
- 290.26 g/mol
- Monoisotopic mass
- 290.01097567
Names & identifiers
- Preferred name
- 7-Nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole
- English name
- NSC228155
- Molecular formula
- C11H6N4O4S
- Molecular weight
- 290.25
Names & synonyms
NSC228155NSC-228155NSC 228155NSC 228155, 10 mM in DMSOEGFR Activator, NSC 228155NSC228155NSC-228155NSC 2281552,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxideEpidermal growth factor receptor,Histone Acetyltransferase,EGFR,HER1,HATs,inhibit,Inhibitor,NSC-228155,HAT,Epigenetic Reader Domain,NSC 228155,ErbB-1
Database identifiers
- CAS
113104-25-9- PubChem CID
- 313619
- DTXSID
DTXSID501357162- ChEMBL
CHEMBL505670- Nikkaji
- J3.102.591E
Properties
Physicochemical properties
- Boiling point
- 627.3 · 627.3±65.0 °C(Predicted)
- Density
- 1.72 · 1.72±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C(protect from light)
- solubility
- 29 mg/mL · ≥29 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- -1.48 · -1.48±0.10(Predicted)
- color
- Light yellow to orange
- InChIKey
- ICCFXXDUYSPKOL-UHFFFAOYSA-N
- SMILES
- S(c3[n+](cccc3)[O-])c1c2n[o]nc2c(cc1)[N+](=O)[O-]
- UNSPSC Code
- 41121801 · 41121801
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
- WGK Germany
- 3 · WGK 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
UsesNSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].
Upstream & downstream products
Upstream raw materials
Suppliers55 total
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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