5,7-Dimethoxy-3-(4-pyridinyl)quinoline
Basic information
- CAS
137206-97-4- Standard SMILES
COc1cc(OC)c2cc(-c3ccncc3)cnc2c1- InChIKey
HBXDLZBPKJEWHZ-UHFFFAOYSA-N- Molecular formula
- C16H14N2O2
- Average molar mass
- 266.29 g/mol
- Monoisotopic mass
- 266.10552769
Overview
a selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase; structure given in first source
Names & identifiers
- Preferred name
- 5,7-Dimethoxy-3-(4-pyridinyl)quinoline
- IUPAC
- 5,7-dimethoxy-3-pyridin-4-ylquinoline
- English name
- 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- Molecular formula
- C16H14N2O2
- Molecular weight
- 266.29
Names & synonyms
137206-97-45,7-Dimethoxy-3-(4-pyridinyl)quinoline5,7-DmpqDTXSID90160107RefChem:913007DTXCID30825985,7-dimethoxy-3-(pyridin-4-yl)quinoline5,7-dimethoxy-3-pyridin-4-ylquinolineQuinoline,5,7-dimethoxy-3-(4-pyridinyl)-CHEMBL68423Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-Bio1_000429
Show more names
DPMQDMPQ2HClDMPQ DIHYDROCHLORIDE5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride
5,7-Dimethoxy-3-(4-pyridyl)quinolineTocris-12225,7-Dimethoxy-3-pyridin-4-yl-quinolineorb1713766SCHEMBL3652915SCHEMBL31060989Bio1_000918Bio1_001407
Database identifiers
- CAS
137206-97-4- PubChem CID
- 3139
- DTXSID
DTXSID90160107- ChEMBL
CHEMBL68423- Nikkaji
- J433.456F
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 44.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 307
Physicochemical properties
- Boiling point
- 441.3 · 441.3±40.0 °C(Predicted)
- Density
- 1.192 · 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml).
- form
- solid
- pka
- 3.58 · 3.58±0.38(Predicted)
- color
- Yellow
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Chemistry & industry
Applications
DescriptionDMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
UsesDMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).
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