Basic information
- CAS
22760-18-5- Standard SMILES
Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1- InChIKey
JTIGKVIOEQASGT-UHFFFAOYSA-N- Molecular formula
- C18H18N2O
- Average molar mass
- 278.3 g/mol
- Monoisotopic mass
- 278.1419132
Overview
Proquazone is a member of pyrimidines.
Names & identifiers
- Preferred name
- Proquazone
- IUPAC
- 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
- English name
- proquazone
- Molecular formula
- C18H18N2O
- Molecular weight
- 278.35
Names & synonyms
PROQUAZONE22760-18-5ArthrexProquazonumProcuazona42VPJ2980SDTXSID4021210RefChem:8698751-isopropyl-4-phenyl-7-methyl-2-(1H)-quinazolineDTXCID801210M01AX13245-203-7
Show more names
43-715BiarsanSaH-43-715ProquazonaSandoz-43-715Proquazone, 10 mM in DMSO
7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-Biarison1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-oneAnthrex; Biarison;RU 43-715; SAN 43-715
Database identifiers
- CAS
22760-18-5- PubChem CID
- 31508
- DTXSID
DTXSID4021210- ChEMBL
CHEMBL268501- ChEBI
CHEBI:135151- UNII
- 42VPJ2980S
- EC Number
- 245-203-7
Properties
Computed structural properties
- XLogP
- 3
- Topological polar surface area
- 32.7 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 2
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 423
Experimental & physicochemical properties
Human DrugsPharmaceuticals
Physicochemical properties
- Melting point
- 137 · 137-138°
- Boiling point
- 436.12 °C · 436.12°C (rough estimate)
- Density
- 1.1707 · 1.1707 (rough estimate)
- refractive index
- 1.57 · 1.5700 (estimate)
- pka
- 0.74 · 0.74±0.20(Predicted)
- FDA UNII
- 42 VPJ2980S · 42VPJ2980S
- ATC code
- 1 AX13 · M01AX13
Chemistry & industry
Pharmacology
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesAnti-inflammatory.
UsesProquazone is a non-steroidal anti-inflammatory drug.
Suppliers12 total
Labnetwork lnc.+86-27-50766799 +86-18062016861 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
Related reactions
6 records
Compound notes
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