Ammonium, (phenylcarbamylmethyl)trimethyl-, iodide
Basic information
- CAS
22913-17-3- Standard SMILES
C[N+](C)(C)CC(=O)Nc1ccccc1.[I-]- InChIKey
CCPHDQUNJSJNQK-UHFFFAOYSA-N- Molecular formula
- C11H17IN2O
- Average molar mass
- 320.17 g/mol
- Monoisotopic mass
- 320.03856
Names & identifiers
- Preferred name
- Ammonium, (phenylcarbamylmethyl)trimethyl-, iodide
- IUPAC
- (2-anilino-2-oxoethyl)-trimethylazanium iodide
- English name
- CAY10568
- Molecular weight
- 0
Names & synonyms
22913-17-3AMMONIUM, (PHENYLCARBAMYLMETHYL)TRIMETHYL-, IODIDERefChem:1076828CAY10568(Phenylcarbamylmethyl)-trimethylammonium iodide(2-anilino-2-oxoethyl)-trimethylazanium;iodideSantinamideorb1692688AKOS040755978HY-138985T37670N,N,N-Trimethyl-2-oxo-2-(phenylamino)ethan-1-aminium iodide
Show more names
CAY10568,CAY-10568(2-anilino-2-oxoethyl)-trimethylazanium:iodideTRIMETHYL ((PHENYLCARBAMOYL)METHYL) AMMONIUM IODIDE
Database identifiers
- CAS
22913-17-3- PubChem CID
- 31569
Properties
Computed structural properties
- Topological polar surface area
- 29.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 3
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 190
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 5 mg/ml; · DMF: 5 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- form
- A crystalline solid
Chemistry & industry
Applications
DescriptionMost local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.1 CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.
UsesCAY10568 is a compound based on QX-314 (HY-101350). CAY10568 is physically smaller and less hydrophobic than the QX-314. CAY10568 can be used in studies of inflammation and pain perception[1].
Related reactions
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Compound notes
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