Sulforidazine
Basic information
- CAS
14759-06-9- Standard SMILES
CN1CCCCC1CCN1c2ccccc2Sc2ccc(S(C)(=O)=O)cc21- InChIKey
FLGCRGJDQJIJAW-UHFFFAOYSA-N- Molecular formula
- C21H26N2O2S2
- Average molar mass
- 402.6 g/mol
- Monoisotopic mass
- 402.14357042
Overview
Sulforidazine is a member of phenothiazines.
Names & identifiers
- Preferred name
- Sulforidazine
- IUPAC
- 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine
- English name
- sulforidazine
- Molecular formula
- C21H26N2O2S2
- Molecular weight
- 402.57
Names & synonyms
SulforidazineImagotanPsychosonInofal14759-06-9Thioridazine-2-sulfoneTPN-12SulforidazinaSolforidazinaSulforidazinumThioridazine sulfoneThioridazine sulphone
Show more names
Thioridazine 2-SulfoneThioridazine EP Impurity EThioridazine Impurity 5 (Thioridazine EP Impurity E)10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-10-[2-[(2RS)-1-Methylpiperidin-2-yl]ethyl]-2-(methylsulfonyl)-10H-phenothiazine10-[2-[(2RS)-1-methylpiperidin-2-yl]ethyl]-2-(methylsulfonyl)-10H-phenothiazine (sulforidazine)10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylsulfonyl)-10H-phenothiazine (Thioridazine Impurity)
10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfonylphenothiazineB7599I244X10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine2-METHANESULFONYL-10-[2-(1-METHYLPIPERIDIN-2-YL)ETHYL]-10H-PHENOTHIAZINE10-(2-(1-methylpiperidin-2-yl)ethyl)-2-methylsulfonylphenothiazine2-methanesulfonyl-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazineRefChem:932382238-818-7
Database identifiers
- CAS
14759-06-9- PubChem CID
- 31765
- DTXSID
DTXSID30864531- ChEMBL
CHEMBL2107268- ChEBI
CHEBI:135644- UNII
- B7599I244X
- EC Number
- 238-818-7
- Nikkaji
- J8.517K
Properties
Computed structural properties
- XLogP
- 4.6
- Topological polar surface area
- 74.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 606
Experimental & physicochemical properties
LogP
4.45
4.45
Human DrugsPharmaceuticals
Melting Point121 - 123 °C
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 121 · 121-123°
- Boiling point
- 589.1 · 589.1±50.0 °C(Predicted)
- Density
- 1 · 1+-.0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator, Under Inert Atmosphere
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.83 · 9.83±0.10(Predicted)
- color
- Off-White to Dark Yellow
- FDA UNII
- 7599 I244X · B7599I244X
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Cellular LocationsMembrane
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesThioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).
Upstream & downstream products
Upstream raw materials
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Related reactions
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Compound notes
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