Basic information
- CAS
161448-79-9- Standard SMILES
CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC.Cl- InChIKey
GDWDBGSWGNEMGJ-UHFFFAOYSA-N- Molecular formula
- C13H21ClN2O3S
- Average molar mass
- 320.84 g/mol
- Monoisotopic mass
- 320.0961414
Overview
Articaine Hydrochloride is the hydrochloride salt form of articaine, an amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine.
Names & identifiers
- Preferred name
- Articaine Hydrochloride
- IUPAC
- methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride
Names & synonyms
ARTICAINE HYDROCHLORIDE23964-57-0Articaine HClUltracainSeptanestUltracaineUbistesineHoe-045HOE 045HOE 40045DTXSID2045444Hoe-40045
Show more names
QS9014Q792DTXCID00254444-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochlorideRefChem:916258Hoe045Hoe40045245-957-7
Database identifiers
- CAS
161448-79-9、23964-57-0- PubChem CID
- 32169
- DTXSID
DTXSID2045444- ChEMBL
CHEMBL1200819- UNII
- QS9014Q792
- EC Number
- 245-957-7
Properties
Computed structural properties
- Topological polar surface area
- 95.7 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 7
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 325
Experimental & physicochemical properties
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anesthetics, Local
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (80.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 216 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (80.6%)
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
ARTICAINE HYDROCHLORIDE
Local Anesthesia [PE]; Amide Local Anesthetic [EPC]; Amides [CS]
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Related reactions
0 records
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Compound notes
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