Basic information
- CAS
60084-10-8- Standard SMILES
NC(=O)c1csc(C2OC(CO)C(O)C2O)n1- InChIKey
FVRDYQYEVDDKCR-UHFFFAOYSA-N- Molecular formula
- C9H12N2O5S
- Average molar mass
- 260.27 g/mol
- Monoisotopic mass
- 260.04669266
Names & identifiers
- Preferred name
- 2-beta-D-Ribofuranosylthiazole-4-carboxamide
- IUPAC
- 2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
- English name
- Tiazofurine
- Molecular formula
- C9H12N2O5S
- Molecular weight
- 260.269
Names & synonyms
MLS0033893202-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamideNSC2861932-.beta.-D-Ribofuranosylthiazole-4-carboxamide4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl-2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamideCHEMBL276286SCHEMBL1651851FVRDYQYEVDDKCR-UHFFFAOYSA-NNSC367734NSC367735NSC367920
Show more names
tiazofurinTCARCI 909NSC-286193Aids014479RiboxamideNSC-286-193TiazofurineAids-014479Tiazofurinum
NSC381855NSC-367734NSC-367735NSC-367920NSC-381855LS-13643NCI60_002347SMR002048975
Database identifiers
- CAS
60084-10-8、92952-33-5、92952-40-4- PubChem CID
- 323701
- ChEMBL
CHEMBL276286
Properties
Computed structural properties
- XLogP
- -1.7
- Topological polar surface area
- 154 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 305
Physicochemical properties
- Melting point
- 145 · 145-146°
- alpha
- 25 · D25 -9° (c = 0.5 in ethanol)
- Density
- 1.4797 · 1.4797 (rough estimate)
- refractive index
- 1.68 · 1.6800 (estimate)
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- color
- White to Pale Beige
- Stability
- Very Very Hygroscopic
- NCI Dictionary of Cancer Terms
- tiazofurin
- FDA UNII
- 82834 RE · ULJ82834RE
- NCI Drug Dictionary
- Riboxamide
- ATC code
- 1 XX18 · L01XX18
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280-P301+P312-P302+P352-P305+P351+P338
Chemistry & industry
Applications
UsesTiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5''-monophosphate (IMP) dehydrogenase.
Upstream & downstream products
Upstream raw materials
Suppliers40 total
上海康恩博医药科技有限公司（科小研试剂）400-1388-521 17510465506 · [email protected]
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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