Normeperidine
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Basic information
- CAS
77-17-8- Standard SMILES
CCOC(=O)C1(c2ccccc2)CCNCC1- InChIKey
QKHMFBKXTNQCTM-UHFFFAOYSA-N- Molecular formula
- C14H19NO2
- Average molar mass
- 233.31 g/mol
- Monoisotopic mass
- 233.14157885
Overview
Pethidine-Intermediate-B, ethyl-4-phenylpiperidine-4-carboxylate is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence. It is a Opiates substance.
Names & identifiers
- Preferred name
- Normeperidine
- IUPAC
- ethyl 4-phenylpiperidine-4-carboxylate
- English name
- NORMEPERIDINE
- Molecular formula
- C14H19NO2
- Molecular weight
- 233.31
Names & synonyms
Ethyl 4-phenylpiperidine-4-carboxylateNormeperidineNorpethidine77-17-8Nordolsin4-Piperidinecarboxylic acid, 4-phenyl-, ethyl esterJG096PMW2NIDS-NP-003DTXSID50227806NSC-23821PETHIDINE-INTERMEDIATE-B, ETHYL-4-PHENYLPIPERIDINE-4-CARBOXYLATERefChem:166645
Show more names
Pethidine Intermediate BNormeperidine solutionNorpethidine (Normeperidine)NORMEPERIDINE,100/MLINMETHANOL
DTXCID60150297201-008-9Ethyl 4-phenylisonipecotate4-Carbethoxy-4-phenylpiperidine4-Phenyl-4-carbethoxypiperidine4-(Ethoxycarbonyl)-4-phenylpiperidine4-Phenylpiperidine-4-carboxylic acid ethyl esterIsonipecotic acid, 4-phenyl-, ethyl ester
Database identifiers
- CAS
77-17-8- PubChem CID
- 32414
- DTXSID
DTXSID50227806- ChEMBL
CHEMBL1052- UNII
- JG096PMW2N
- EC Number
- 201-008-9
- Nikkaji
- J104.492C
Properties
Computed structural propertiesFilling in
- XLogP
- 2
- Topological polar surface area
- 38.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 4
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 253
Experimental & physicochemical properties
DrugsDEA Schedule II Controlled Substance -> Opiates
Physicochemical properties
- Melting point
- 36 · 36-38 °C
- Boiling point
- 155 °C · 155 °C(Press: 3.5 Torr)
- Density
- 1.064 · 1.064±0.06 g/cm3(Predicted)
- Flash point
- 11 °C · 11 °C
- storage temp.
- 2 · 2-8°C
- pka
- 9.58 · 9.58±0.10(Predicted)
- FDA UNII
- 96 PMW2N · JG096PMW2N
- Symbol(GHS)
- 2 · GHS02,GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- 225 · H225-H301+H311+H331-H370
- Precautionary statements
- 210 · P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P260-P301+P310-P311
- Hazard Codes
- F,T
- Risk Statements
- 11 · 11-23/24/25-39/23/24/25
- Safety Statements
- 7 · 7-16-36/37-45
- RIDADR
- 1230 · UN 1230 3/PG 2
- WGK Germany
- 1 · 1
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationDEA schedule II controlled substance
Other Safety InformationIMAP assessments - 4-Piperidinecarboxylic acid, 4-phenyl-, ethyl ester: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (97.5%)
Safety data
- wgk
- 1
- ridadr
- UN 1230 3/PG 2
- risk_code
- 11-23/24/25-39/23/24/25
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS06,GHS08
- hazard_code
- F,T
- safety_code
- 7-16-36/37-45
- Hazard statements
- H225-H301+H311+H331-H370
- Precautionary statements
- P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P260-P301+P310-P311
Chemistry & industry
Pharmacology
Metabolism/MetabolitesNormeperidine is a known human metabolite of meperidine.
MeSH Pharmacological Classification
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Cellular LocationsMembrane
Applications
UsesNORMEPERIDINE is used as an intermediate for the drug diphenoxylate (phenoxypiperidine hydrochloride).
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
27 records
Compound notes
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