Basic information
- CAS
55750-61-3- Standard SMILES
O=C(CN1C(=O)C=CC1=O)ON1C(=O)CCC1=O- InChIKey
TYKASZBHFXBROF-UHFFFAOYSA-N- Molecular formula
- C10H8N2O6
- Average molar mass
- 252.18 g/mol
- Monoisotopic mass
- 252.03823598
Names & identifiers
- Preferred name
- Maleimidoacetic acid N-hydroxysuccinimide ester
- IUPAC
- (2,5-dioxopyrrolidin-1-yl) 2-(2,5-dioxopyrrol-1-yl)acetate
- English name
- N-Succinimidyl maleimidoacetate
- Molecular formula
- C10H8N2O6
- Molecular weight
- 252.18
Names & synonyms
Maleimidoacetic acid N-hydroxysuccinimide esterRefChem:800784637-252-155750-61-3n-succinimidyl maleimidoacetateAMAS2,5-Dioxopyrrolidin-1-yl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetate(2,5-dioxopyrrolidin-1-yl) 2-(2,5-dioxopyrrol-1-yl)acetateN-SMPMFCD00133523N-(|A-Maleimidoacetoxy)succinimideN-(alpha-Maleimidoacetoxy)succinimide
Show more names
Azido-PEG1-Val-Cit-PABC-PNPMaleiMidoaceticAMAS, 10 mM in DMSON-(α-MaleiMidoacetoxy)succiMide
Maleimidoacetic Acid N-Succinimidyl Estera-Maleimidoacetic acid-NHS(AMAS)GS-56682,5-Dioxopyrrolidin-1-yl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl);acetate1H-Pyrrole-1-acetic acid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl estera-Maleimidoacetic acid-NHSAMY21437N-(alfa-Maleimidoacetoxy)succinimide
Database identifiers
- CAS
55750-61-3- PubChem CID
- 3299229
- DTXSID
DTXSID80391201
Properties
Computed structural properties
- XLogP
- -1.5
- Topological polar surface area
- 101 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 461
Physicochemical properties
- Melting point
- 174 · 174-175°C
- Boiling point
- 430.1 · 430.1±47.0 °C(Predicted)
- Density
- 1.63 · 1.63±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
- pka
- -2.69 · -2.69±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C10H8N2O6/c13-6-1-2-7(14)11(6)5-10(17)18-12-8(15)3-4-9(12)16/h1-2H,3-5H2
- InChIKey
- TYKASZBHFXBROF-UHFFFAOYSA-N
- SMILES
- N1(CC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O
- CAS DataBase Reference
- 55750 · 55750-61-3
- UNSPSC Code
- 12352106 · 12352106
- NACRES
- 7 · NC.07
- Symbol(GHS)
- 7 · GHS07
Safety & regulation
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- hs_code
- 29280000
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P305+P351+P338
Chemistry & industry
Applications
UsesA hetero-bifunctional cross-linking reagent for the preparation of protein-protein or protein-hapten conjugates.
UsesMaleimidoacetic acid N-hydroxysuccinimide ester is a crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 spacer arm. This configuration allows for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
Related reactions
1 records
Compound notes
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