Etizolam

HCID 3307CAS 40054-69-1

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Basic information

Standard SMILES: CCc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl
InChIKey: VMZUTJCNQWMAGF-UHFFFAOYSA-N
Molecular formula: C17H15ClN4S
Average molar mass: 342.855 g/mol
Monoisotopic mass: 342.07059516

Names & identifiers

Preferred name: Etizolam
IUPAC: 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
English name: ETIZOLAM
Molecular formula: C17H15ClN4S
Molecular weight: 342.85

Names & synonyms

azepinEtizola4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepinedepasY-7131EtizoLahr3219ETIZOLAMtuoqigaoBrn 0572740

Database identifiers

CAS: 40054-69-1
PubChem CID: 3307
DTXSID: DTXSID0023030
ChEMBL: CHEMBL1289779
ChEBI: CHEBI:31583
UNII: A76XI0HL37
EC Number: 662-368-4
Nikkaji: J23.586E

Properties

Physicochemical properties

Melting point: 147 · 147-148℃
Boiling point: 264.5 °C · 264.5°C (rough estimate)
Density: 1.43 · 1.43
refractive index: 1.61 · 1.6100 (estimate)
Flash point: 9 °C · 9°C
storage temp.: -20 °C · -20°C
solubility: 5 mg/ml; · DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form: A neat solid
pka: 2.37 · 2.37±0.40(Predicted)
CAS DataBase Reference: 40054 · 40054-69-1
EWG's Food Scores: 1 · 1
FDA UNII: 76 XI0HL37 · A76XI0HL37
ATC code: 5 BA19 · N05BA19
Symbol(GHS): 2 · GHS02, GHS06, GHS08
Signal word: Danger
Hazard statements: 225 · H225-H301+H311+H331-H370
Precautionary statements: 210 · P210-P260-P280-P301+P310-P311
Hazard Codes: F,T
Risk Statements: 11 · 11-23/24/25-39/23/24/25
Safety Statements: 7 · 7-16-36/37-45
RIDADR: 1230 · UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1 · 1
Toxicity: 50 in · LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari)

Safety & regulation

Safety data

wgk: 1
ridadr: UN1230 - class 3 - PG 2 - Methanol, solution
Toxicity: LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari)
risk_code: 11-23/24/25-39/23/24/25
Signal word: Danger
Symbol(GHS): GHS02, GHS06, GHS08
hazard_code: F,T
safety_code: 7-16-36/37-45
Hazard statements: H225-H301+H311+H331-H370
Precautionary statements: P210-P260-P280-P301+P310-P311

Chemistry & industry

Applications · 4 items

DescriptionEtizolam is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety or panic attacks. It has amnesic, anxiolytic, anticonvulsant, and hypnotic, sedative and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system.

DescriptionEtizolam is a potent thienodiazepine anxiolytic closely related to brotizolam. Pharmacologically, however, its profile most resembles that of diazepam.

UsesEtilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain. Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks.

UsesNasal Dilator