Minaprine Hydrochloride
Basic information
- CAS
25953-17-7- Standard SMILES
Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1.Cl.Cl- InChIKey
GNUCGROXDZMCJI-UHFFFAOYSA-N- Molecular formula
- C17H24Cl2N4O
- Average molar mass
- 371.3 g/mol
- Monoisotopic mass
- 370.1327168
Overview
See also: Minaprine (has active moiety).
Names & identifiers
- Preferred name
- Minaprine Hydrochloride
- IUPAC
- 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine;dihydrochloride
- English name
- Minaprine dihydrochloride
- Molecular formula
- C17H24Cl2N4O
- Molecular weight
- 371.30466
Names & synonyms
Minaprine dihydrochlorideMINAPRINE HYDROCHLORIDEMinaprine HCl30038CBDTXSID204586482Y7NT6DFTNSC-3057423-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine dihydrochloride30038-CBDTXCID0025864N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine dihydrochlorideMorpholine, 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)-, dihydrochloride
Show more names
Ag 620Agr 1240Minaprine dihydrochloride, 10 mM in DMSOMonoamine Oxidase,MAO,Minaprine dihydrochloride,inhibit,Inhibitor,MinaprinePyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochlorideMorpholine, 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-, dihydrochloride
CHEBI:51040NSC305742RefChem:15894125953-17-7Minaprine (dihydrochloride)Minaprine hydrochloride [USAN]AGR 6204-methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine dihydrochloride
Database identifiers
- CAS
25953-17-7- PubChem CID
- 33254
- DTXSID
DTXSID2045864- ChEMBL
CHEMBL1364551- UNII
- 82Y7NT6DFT
Properties
Computed structural properties
- Topological polar surface area
- 50.3 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 316
Experimental & physicochemical properties
Collision Cross Section173.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 182 ° · 182°
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 100 mg/mL · DMSO : ≥ 100 mg/mL (269.32 mM)
- form
- Solid
- color
- White to off-white
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 82 Y7NT6DFT · 82Y7NT6DFT
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H332-H335
- Precautionary statements
- 261 · P261-P280-P305+P351+P338
- Toxicity
- 50 intraperitoneal · LD50 intraperitoneal in mouse: 63mg/kg
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 intraperitoneal in mouse: 63mg/kg
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Applications
UsesAntidepressant.
Upstream & downstream products
Upstream raw materials
Suppliers
Loading…
Open inquiries
Loading…
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…