Fosamine

For acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Occupational exposure to fosamine occurs through dermal contact and inhalation of dust and sprays, especially to workers applying the compound as a herbicide. Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine can cause moderate eye injury or irritation. In one subchronic oral study, the laboratory animals given the highest dose exhibited some statistically significant effects, including effects to the kidneys, bladder and decreases in body weight.

LD50 Mallard duck oral more than 4150 mg (as emulsifiable concentrate)/kg

LD50 Bobwhite quail oral more than 4150 mg (as emulsifiable concentrate)/kg

LC50 Bluegill 278 mg active ingredient (as emulsifiable concentrate)/l/96 hr /Conditions of bioassay not specified/

LC50 Rainbow trout more than 415 mg active ingredient (as emulsifiable concentrate)/l/96 hr /Conditions of bioassay not specified/

For more Ecotoxicity Values (Complete) data for FOSAMINE (6 total), please visit the HSDB record page.

AQUATIC FATE: STUDIES SHOWED THAT IT IS STABLE FOR EXTENDED PERIODS IN NEUTRAL OR ALKALINE WATER.

TERRESTRIAL FATE: UNDER FIELD CONDITIONS T/2 IN SOIL WAS APPROX 1 WK FOLLOWING TREATMENT OF PRACTICAL USE LEVELS.

Terrestrial Fate: Rapidly decomposed by soil microorganisms. Half-life in soil is about 10 days.

TERRESTRIAL FATE: AT 10 PPM IT DID NOT AFFECT THE SOIL POPULATION COUNT OF FUNGI & BACTERIA OVER AN 8 WK PERIOD. IT HAD NO EFFECT ON THE SOIL NITRIFICATION PROCESS.

For more Environmental Fate (Complete) data for FOSAMINE (7 total), please visit the HSDB record page.

Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine is not a skin sensitizer.

In field studies (conducted in DE, FL, and IL), greenhouse studies, and soil column studies, fosamine-ammonium was found to leach very little, either downward or laterally(1); most undegraded fosamine-ammonium remained in the upper 4 inches of soil(1).

Laboratory studies in biometer flasks on two soil types (pHs of 6.4 and 6.5) treated with C-14 fosamine-ammonium demonstrated rapid degradation by microbial action(1); 14-CO2 evolution in nonsterile soils reached 45-75% after 90 days(1); in soil sterilized by a single autoclaving at steam pressure for 15 min, 14-CO2 evolution was only 8-18%(2).

Based upon a water solubility of 1.79 kg/L at 25 °C(1), the BCF of fosamine-ammonium can be estimated to be 0.2 from a recommended regression derived equation(2,SRC). The BCF value indicates that bioconcentration in aquatic organisms is not an important fate process(SRC). In bioaccumulation studies using channel catfish and (14)C fosamine-ammonium, fosamine-ammonium BCFs of less than 1 were measured(2).

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Ammonium ethyl carbamolyphosphonate is found on List B. Case No: 2355; Pesticide type: Herbicide; Case Status: RED Approved 12/94; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Ammonium ethyl carbamolyphosphonate; Data Call-in (DCI) Date(s): 06/11/91, 03/14/95; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.