Basic information
- CAS
26097-80-3- Standard SMILES
CC(C)OC(=O)Nc1ccc2nc(-c3cscn3)[nH]c2c1- InChIKey
QZWHWHNCPFEXLL-UHFFFAOYSA-N- Molecular formula
- C14H14N4O2S
- Average molar mass
- 302.35 g/mol
- Monoisotopic mass
- 302.08374688
Overview
A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.
Names & identifiers
- Preferred name
- Cambendazole
- IUPAC
- propan-2-yl N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]carbamate
- English name
- Urokinase
- Molecular formula
- C21H25BrN2O3
- Molecular weight
- 0
Names & synonyms
Cambendazole26097-80-3CambendazolCamvetCamdanCambendazolumNSC-377071DTXSID0046852Isopropyl 2-(4-triazolyl)-5-benzimidazolecarbamate079X63S3DUCarbamic acid, (2-(4-thiazolyl)-1H-benzimidazol-5-yl)-, 1-methylethyl esterDTXCID8026852
Show more names
uktcuke-PPAUronaseUrokisewin22005UROKINASEUrolinasewin-kinaseurokinaase
Carbamic acid, [2-(4-thiazolyl)-1H-benzimidazol-5-yl]-, 1-methylethyl esterRefChem:9179435-Isopropoxycarbonylamino-2-(4-thiazoyl)benzimidazolepropan-2-yl N-(2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazol-5-yl)carbamate247-459-5NovazoleNovibenBonlam
Database identifiers
- CAS
26097-80-3、9039-53-6- PubChem CID
- 33309
- DTXSID
DTXSID0046852- ChEMBL
CHEMBL290578
Properties
Computed structural properties
- XLogP
- 2.9
- Topological polar surface area
- 108 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 382
Experimental & physicochemical properties
Human DrugsPharmaceuticals
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- Soluble in water.
- form
- powder
- color
- white
- Water Solubility
- 100 · Reconstitute in water at 100µg/ml
- Specific Activity
- 500 units/mg · ≥500units/mg protein
- CAS DataBase Reference
- 9039 · 9039-53-6
- NCI Dictionary of Cancer Terms
- u-plasminogen activator; urokinase; urokinase-plasminogen activator
- FDA UNII
- 83 G67E21XI · 83G67E21XI
- ATC code
- 1 AD04 · B01AD04
- EPA Substance Registry System
- Kinase (enzyme-activating), uro- (9039-53-6)
- UNSPSC Code
- 12352204 · 12352204
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 97.5% (39 of 40) of all reports.
Not Classified
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory.
Warning
H361 (97.4%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Hazard information
Hazard Classes and Categories
Repr. 2 (97.4%)
Not Classified
Safety data
- F
- 10-21
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- OB8900000
- hs_code
- 3507909090
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- hazard_code
- B
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H334
- Hazard Classifications
- Resp. Sens. 1
- Precautionary statements
- P261-P284-P501
Chemistry & industry
Pharmacology
ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationSubstances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
DescriptionUrokinase is an enzyme that is extracted from human urine or kidney cells, which directly cleaves specific peptide bonds, in particular the Arg-560–Val-561 bond in the plasminogen molecule, thus transforming it into plasmin.
UsesIt is used for the same indications as streptokinase.
UsesThe effect of systemic administration of urokinase is unclear. One study reported the effectiveness of superselective ophthalmic artery fibrinolytic therapy of urokinase for CRVO. Urokinase was infused through a microcatheter into the ostium of the ophthalmic artery via the femoral artery. Six eyes of 26 patients had a significant improvement in VA 24 hours after the fibrinolysis; eyes with combined central retinal artery occlusion and CRVO with recent visual impairment appeared to be the most responsive.
UsesPlasminogen activator; fibrinolytic; enzyme.
General DescriptionUrokinase (Abbokinase) is a glycosylatedserine protease consisting of 411 amino acid residues,which exists as two polypeptide chains connected by a singledisulfide bond. It is isolated from human urine or tissueculture of human kidneys. The only known substrate ofurokinase is plasminogen, which is activated to plasmin, afibrinolytic enzyme. Unlike streptokinase, urokinase is adirect activator of plasminogen. Urokinase is nonantigenicbecause it is an endogenous enzyme and, therefore, may beused when streptokinase use is impossible because of antibodyformation. It is administered intravenously or by theintracoronary route. Its indications are similar to those ofstreptokinase.
Related reactions
0 records
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Compound notes
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