Basic information
- CAS
38101-59-6- Standard SMILES
NC(CCC(=O)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O- InChIKey
LLEUXCDZPQOJMY-UHFFFAOYSA-N- Molecular formula
- C16H19N3O5
- Average molar mass
- 333.34 g/mol
- Monoisotopic mass
- 333.13247072
Overview
RN refers to L-isomer; a naturally occurring thymic immunomodulator
Names & identifiers
- Preferred name
- alpha-Glutamyltryptophan
- IUPAC
- 4-amino-5-[[1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
- English name
- H-Glu-Trp-OH
- Molecular formula
- C16H19N3O5
- Molecular weight
- 333.34
Names & synonyms
RefChem:915520DTXCID50201843DTXSID10865900alpha-GlutamyltryptophanSCHEMBL2042188CHEMBL4553149H-Glu-Trp-OH; L-Glu-L-Trp;LLEUXCDZPQOJMY-UHFFFAOYSA-NSTL504719AKOS037487920NS001231994-amino-5-[[1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxo-pentanoic acid
Show more names
OglufanideGlutamyltryptophanL-Glutamyl-L-tryptophanGLU-TRPTimogenZ-Glu-TrpCcris 8677NSC 334073Glu-Trp HAc
EW
Database identifiers
- CAS
38101-59-6- PubChem CID
- 333386
- ChEMBL
CHEMBL4553149
Properties
Computed structural properties
- XLogP
- -2.7
- Topological polar surface area
- 146 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 8
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 484
Physicochemical properties
- Melting point
- 121 · 121-122℃
- Boiling point
- 738.9 · 738.9±60.0 °C(Predicted)
- Density
- 1.428 · 1.428
- storage temp.
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- solubility
- 15.5 mg/mL · DMSO : 15.5 mg/mL (46.50 mM)
- form
- Solid
- pka
- 3.09 · 3.09±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1/C16H19N3O5/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/s3
- InChIKey
- LLEUXCDZPQOJMY-PZILLZCRNA-N
- SMILES
- C(C1=CNC2=CC=CC=C12)[C@@H](C(=O)O)NC(=O)[C@@H](N)CCC(=O)O |&1:10,17,r|
- FDA UNII
- 4 RHY598T5U · 4RHY598T5U
- Symbol(GHS)
- 7 · GHS07,GHS02
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H226
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS02
- Hazard statements
- H315-H319-H226
- Precautionary statements
- P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Chemistry & industry
Applications
UsesTreatment of Kaposi’s sarcoma and solid tumor cancers (angiogenesis inhibitor); immunomodulator.
UsesH-Glu-Trp-OH, has show to have potential antiangiogenic and immunomodulating activities. It inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.
Suppliers100 total
韶远科技(上海)有限公司4000665055 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
江苏生康迈翔科技有限公司18217475093 · [email protected]
郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
上海海皋科技有限公司021-57646680 18306277365 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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