Halofenate
Basic information
- CAS
24136-24-1- Standard SMILES
CC(=O)NCCOC(=O)C(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1- InChIKey
BJBCSGQLZQGGIQ-UHFFFAOYSA-N- Molecular formula
- C19H17ClF3NO4
- Average molar mass
- 415.8 g/mol
- Monoisotopic mass
- 415.0798202
Overview
Halofenate is a selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulator with antilipidemic activity. Halofenate also decreases fasting plasma glucose in type 2 diabetic patients, but not normoglycemic subjects.
Names & identifiers
- Preferred name
- Halofenate
- IUPAC
- 2-acetamidoethyl 2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate
- English name
- HALOFENATE
- Molecular formula
- C19H17ClF3NO4
- Molecular weight
- 415.79
Names & synonyms
HALOFENATE26718-25-2MK 185HalofenatoMK-185HalofenatumK9TZK4MNO6DTXSID9023120Benzeneacetic acid, 4-chloro-alpha-(3-(trifluoromethyl)phenoxy)-, 2-(acetylamino)ethyl esterMK185RefChem:389032DTXCID103120
Show more names
Lipivas4-Chloro-α-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl esterBenzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester
Halofenate; Lipivas2-acetamidoethyl 2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetateCHEMBL456071Halofenatum [INN-Latin]Halofenato [INN-Spanish]UNII-K9TZK4MNO6Halofenate [USAN:INN:BAN]4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Database identifiers
- CAS
24136-24-1、26718-25-2- PubChem CID
- 33584
- DTXSID
DTXSID9023120- ChEMBL
CHEMBL456071- UNII
- K9TZK4MNO6
- Nikkaji
- J10.438H
Properties
Computed structural properties
- XLogP
- 4.3
- Topological polar surface area
- 64.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 8
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 524
Physicochemical properties
- Boiling point
- 551.1 · 551.1±50.0 °C(Predicted)
- Density
- 1.331 · 1.331±0.06 g/cm3(Predicted)
- pka
- 15.32 · 15.32±0.46(Predicted)
- FDA UNII
- 9 TZK4MNO6 · K9TZK4MNO6
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
Applications
UsesAntihyperlipoproteinemic; uricosuric.
UsesHalofenate is a selective peroxisome proliferator-activated receptor γ (PPARγ) modulator with antidiabetic activity.
Related reactions
9 records
Compound notes
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