Tris(isopropylphenyl)phosphate

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tris(isopropylphenyl)phosphate can be estimated to be 1.2X10+6(SRC). According to a classification scheme(2), this estimated Koc value suggests that tris(isopropylphenyl)phosphate is expected to be immobile in soil.

BCF ranges of 6.9 to 17 and 20 to 43 were reported in fish for tris(isopropylphenyl)phosphate at concentrations of 2 and 0.2 mg/L respectively, using carp (Cyprinus carpio) which were exposed over an 8-week period(1). According to a classification scheme(2), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for tris(4-iisopropylphenyl)phosphate is estimated as 2.9X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). By analogy, this Henry's Law constant indicates that tris(isopropylphenyl)phosphate is expected to be essentially nonvolatile from water or moist soil surfaces(2). Tris(isopropylphenyl)phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.1X10-8 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ Five male and 5 female Wistar rats received a single oral dose of 20,000 mg/kg bw of isopropylated triphenyl phosphates. The animals were observed for 14 days, after which they were sacrificed, necropsied and their organs examined for gross lesions. No male rats died but 4 of the 5 females. No clinical signs were reported. /Isopropylated triphenyl phosphates/

/LABORATORY ANIMALS: Acute Exposure/ Three New Zealand White rabbits were treated with 0.1 mL (110 mg) isopropylated triphenyl phosphate in their conjunctival sac of the right eye. Each treated eye was held closed for about one second after administration. The eyes were evaluated for irritation using the Draize method at 1, 24, 48 and 72 hours after dosing. Slight conjunctival redness was observed in two treated eyes 24 hours after dosing. The irritation had disappeared by the 48-hour observation. The Primary Eye Irritation Index was 1.3 at 24 hours and 0 at 48 and 72 hours. Thus, isopropylated triphenyl phosphate caused very slight irritation. /Isopropylated triphenyl phosphates/

/LABORATORY ANIMALS: Acute Exposure/ Eye irritation from isopropylated triphenyl phosphate was investigated in 9 rabbits. The treated eyes of 6 rabbits were unwashed through the 7-day observation period whereas the eyes of 3 rabbits were washed about 4 seconds after treatment. The treated eyes were examined at 24, 48, 72 hours and 7 days after treatment. There was no irritation in any of the treated eyes at any of the observation times. /Isopropylated triphenyl phosphates/

/LABORATORY ANIMALS: Acute Exposure/ Isopropylated triphenyl phosphate (0.1 mL or 110 mg) was applied on the shaved backs of 3 New Zealand rabbits. The test site was wrapped with gauze, which was covered with cheesecloth. The test material was in contact with the skin for 4 hours. The sites were scored at 4.5, 24, 48 and 72 hours after they were unwrapped using the method of Draize. No irritation was observed and the test substance was classified as non-irritating. The Primary Irritation Score was 0. /Isopropylated triphenyl phosphates/

For more Non-Human Toxicity Excerpts (Complete) data for TRIS(ISOPROPYLPHENYL)PHOSPHATE (10 total), please visit the HSDB record page.

Tris(isopropylphenyl)phosphate is expected to undergo hydrolysis in the environment due to the presence of functional groups that hydrolyze under environmental conditions(1). Aryl phosphates have been shown to hydrolyze, especially under basic conditions(2). Tris(isopropylphenyl)phosphate does not contain chromophores that absorb at wavelengths >290 nm(1) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Occupational exposure to tris(isopropylphenyl)phosphate may occur through inhalation and dermal contact with this compound at workplaces where tris(isopropylphenyl)phosphate is produced or used. Use data indicate that the general population may be exposed to tris(isopropylphenyl)phosphate via inhalation of ambient air in the vicinity of fires involving PVC products. (SRC)

NIOSH (NOES Survey 1981-1983) has statistically estimated that 988 workers (797 of these were female) were potentially exposed to tri-(4-isopropylphenyl)phosphate in the US(1). /Tri-(4-isopropylphneyl)phosphate/

Tris(isopropylphenyl)phosphate's production and use as a flame retardant primarily in PVC plastics may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure for the 4-isomer of 2.1X10-8 mm Hg at 25 °C indicates tris(isopropylphenyl)phosphate will exist solely in the particulate phase in the atmosphere. Particulate-phase tris(isopropylphenyl)phosphate will be removed from the atmosphere by wet and dry deposition. Tris(isopropylphenyl)phosphate does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, tris(isopropylphenyl)phosphate is expected to be immobile based upon an estimated Koc of 1.2X10+6. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.9X10-7 atm-cu m/mole for the 4-isomer. Tris(isopropylphenyl)phosphate is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is not an important environmental fate process in soil or water. If released into water, tris(isopropylphenyl)phosphate is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. A BCF range of 6.9 to 42 suggests bioconcentration in aquatic organisms is low. Hydrolysis is expected to be an important environmental fate process since this compound contains functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to tris(isopropylphenyl)phosphate may occur through inhalation and dermal contact with this compound at workplaces where tris(isopropylphenyl)phosphate is produced or used. Use data indicate that the general population may be exposed to tris(isopropylphenyl)phosphate via inhalation of ambient air in the vicinity of fires involving PVC products. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/