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Basic information
- CAS
314045-39-1- Standard SMILES
O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1- InChIKey
HBFNKZVNDOYJDJ-UHFFFAOYSA-N- Molecular formula
- C24H24N6O2S3
- Average molar mass
- 524.68 g/mol
Names & identifiers
- Preferred name
- bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
- English name
- bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
- Molecular formula
- C24H24N6O2S3
- Molecular weight
- 524.68
Names & synonyms
BPTESCS-1542BPTES, 10 mM in DMSOGlutaminase Inhibitor IIGlutaminase Inhibitor II, BPTESGlutaminase,inhibit,Inhibitor,BPTESbis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfidebis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl SulfideBis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfideN,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Database identifiers
- CAS
314045-39-1- PubChem CID
- 3372016
- ChEMBL
CHEMBL2177757- EC Number
- 803-573-2
- Nikkaji
- J2.510.616D
Properties
Physicochemical properties
- Density
- 1.42 · 1.420±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- 10 mg/mL, · DMSO: soluble10mg/mL, clear
- pka
- 9.13 · 9.13±0.50(Predicted)
- form
- powder
- color
- white to beige
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- HBFNKZVNDOYJDJ-UHFFFAOYSA-N
- SMILES
- S(CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1)CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
- target organs
- Respiratory system
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26
- WGK Germany
- 3 · 3
- HS Code
- 2934999090 · 2934999090
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- hs_code
- 2934999090
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P305+P351+P338
Chemistry & industry
Applications
DescriptionBPTES (314045-39-1) is a potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6
UsesBis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.
Suppliers87 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
北京索莱宝科技有限公司
Related reactions
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Compound notes
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