Basic information
- CAS
356-12-7- Standard SMILES
CC(=O)OCC(=O)C12OC(C)(C)OC1CC1C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C- InChIKey
WJOHZNCJWYWUJD-UHFFFAOYSA-N- Molecular formula
- C26H32F2O7
- Average molar mass
- 494.5 g/mol
- Monoisotopic mass
- 494.21160968
Overview
See also: Fluocinonide (annotation moved to).
Names & identifiers
- Preferred name
- Metosyn
- IUPAC
- [2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxoethyl] acetate
- English name
- Fluocinonide
- Molecular formula
- C26H32F2O7
- Molecular weight
- 494.52
Names & synonyms
TopsynMetosynRefChem:818776BestasoneBiscosalCortalarStradermTopsyminSynalar acetatePregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-FluocinomideLidex E
Show more names
fluocinolideFluocinolone Acetonide EP Impurity MVanosFluoxetine acetateFluocinonide Acetonide(6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dioneLidexLonidetopsym
C26H32F2O7DermaplusSynalateTopsyneMFCD00079302fluocinonide; Fluocinonide;SCHEMBL13026147WJOHZNCJWYWUJD-UHFFFAOYSA-N
Database identifiers
- CAS
356-12-7- PubChem CID
- 3382
Properties
Computed structural properties
- XLogP
- 3.2
- Topological polar surface area
- 99.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 4
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 1,070
Experimental & physicochemical properties
DrugsPharmaceuticals
Human DrugsBreast Feeding; Lactation; Corticosteroids, Topical; Glucocorticoids; Anti-Inflammatory Agents
Physicochemical properties
- Melting point
- 309 °C · 309 °C
- alpha
- 83 ° · D +83° (chloroform)
- Boiling point
- 235 °C · 235°C (rough estimate)
- Density
- 1.2001 · 1.2001 (estimate)
- storage temp.
- 2 · 2-8°C
- solubility
- 19 mg/mL · DMSO: ≥19mg/mL
- form
- powder
- pka
- 12.77 · 12.77±0.70(Predicted)
- color
- white to tan
- optical activity
- 75 to · [α]/D +75 to +90°, c = 1 in dichloromethane
- Water Solubility
- 0.53 mg/L · 0.53mg/L(25 ºC)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Safety data
- wgk
- 3
- rtecs
- TU3831000
- ridadr
- UN 2811 6.1/PG 2
- hs_code
- 2937220000
- Toxicity
- guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982.
- risk_code
- 28-63
- Signal word
- Danger
- Symbol(GHS)
- GHS06,GHS08
- hazard_code
- T+
- safety_code
- 22-25-28-36/37/39-45
- hazard_class
- 6.1(a)
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- packing_group
- I
- Hazard statements
- H300-H361
- Hazard Classifications
- Acute Tox. 2 OralRepr. 2
- Precautionary statements
- P201-P301+P310+P330
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Applications
UsesFluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
UsesGlucocorticoid; anti-inflammatory.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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