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Fluphenazine Decanoate

HCID 3388
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
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Basic information

CAS
5002-47-1
Standard SMILES
CCCCCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
Molecular formula
C32H44F3N3O2S
Average molar mass
591.8 g/mol
Monoisotopic mass
591.31063331

Overview

Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and a prodrug. It is an organofluorine compound, a member of phenothiazines, a N-alkylpiperazine and a decanoate ester. It is functionally related to a fluphenazine.

Names & identifiers

Preferred name
Fluphenazine Decanoate
IUPAC
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
English name
Fluphenazine decanoate
Molecular formula
C32H44F3N3O2S
Molecular weight
591.77

Names & synonyms

Fluphenazine decanoate5002-47-1ModecateLyogenModiten depotDapotum DFluphenazine depotProlixin decanoateFlufenazine decanoateFluorophenazine decanoateFluphenaline decanoateDEPOT
Show more names
ecanoatedapotumdsq10,733moditendepotzinyl)ethylesterprolixindecanoatefluphenazinedepotflufenazinedecanoate
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoateNSC-169510FMU62K1L3CFluphenazini decanoasDTXSID7023069QD-10733SQ-10733NSC169510

Database identifiers

CAS
5002-47-1
PubChem CID
3388
DTXSID
DTXSID7023069
ChEMBL
CHEMBL1200854
ChEBI
CHEBI:5124
UNII
FMU62K1L3C

Properties

Computed structural properties

XLogP
9
Topological polar surface area
61.3 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
9
Rotatable bonds
16
Heavy atoms
41
Formal charge
0
Complexity
765

Experimental & physicochemical properties

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physicochemical properties

Melting point
30 · 30-32°
Boiling point
658.1 · 658.1±55.0 °C(Predicted)
Density
1.149 · 1.149±0.06 g/cm3(Predicted)
storage temp.
-20 °C · Store at -20°C
solubility
Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
form
Oil
pka
7.32 · 7.32±0.10(Predicted)
color
Light yellow to yellow
Major Application
pharmaceutical (small molecule)
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
SMILES
FC(F)(F)c1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)CCOC(=O)CCCCCCCCC

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Danger

H300 (40%): Fatal if swallowed [Danger Acute toxicity, oral]

P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 30 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 2 (40%)

Safety data

wgk
WGK 3
rtecs
HE0525000
ridadr
3249
Signal word
Danger
Symbol(GHS)
GHS06,GHS08
hazard_class
6.1(a)
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
packing_group
II
Hazard statements
H300-H361
Hazard Classifications
Acute Tox. 2 OralRepr. 2
Precautionary statements
P201-P202-P264-P270-P280-P301+P310

Chemistry & industry

Pharmacology

FDA Pharmacological Classification · 2 items

FLUPHENAZINE DECANOATE

Phenothiazines [CS]; Phenothiazine [EPC]

MeSH Pharmacological Classification · 2 items

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

Applications

UsesFluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.

Suppliers63 total

北京华美互利生物化工010-56205725 · [email protected]
上海策嵘生物科技有限公司[email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
武汉云尚本草医药有限公司

Related reactions

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New reaction record

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
EC Number
225-672-4
Nikkaji
J13.702B
CAS DataBase Reference
5002 · 5002-47-1
FDA UNII
62 K1L3C · FMU62K1L3C
UNSPSC Code
41116107 · 41116107
NACRES
24 · NA.24
Protein binding
90 % · >90%
Excreted unchanged in urine
20 % · 20%
Volume of distribution
10 · 10
Biological half-life
6 · 6-9 days / 14-26 days
Symbol(GHS)
6 · GHS06,GHS08
Signal word
Danger
Hazard statements
300 · H300-H361
Precautionary statements
201 · P201-P202-P264-P270-P280-P301+P310
RIDADR
3249 · 3249
WGK Germany
3 · WGK 3
RTECS
525000 · HE0525000
HazardClass
6.1 · 6.1(a)
PackingGroup
II
Storage Class
6.1 A · 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
Hazard Classifications
2 OralRepr · Acute Tox. 2 OralRepr. 2
13816696056 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
普善实业(陕西)有限公司029-81310890 18165209495 · [email protected]
Jai Radhe Sales+(91)-(79)-26431096/65255722 · [email protected]
湖北辰心化工有限公司18696113233 · [email protected]
Syntechem Co.,Ltd[email protected]
安耐吉化学&3A(安徽泽升科技有限公司)021-58432009 400-005-6266 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
贵州迪大科技有限责任公司0851-8475-2296 18096062265 · [email protected]
大赛璐药物手性技术(上海)有限公司021-50460086-9 15921403865 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]
南京世洲生物科技有限公司13675144456 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
桦特昇生物科技(武汉)有限公司027-59207879 1972026995 18140587686 · [email protected]
珠海安哲生物科技有限公司13169972583 · [email protected]
上海昕凯医药科技有限公司21-619849051-1 18521059765 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
西安美川生物科技有限公司029-89275612 +8618991951683 · [email protected]
北京汇科盈生物科技有限公司15210661751 · [email protected]
艾吉析科技(上海)有限公司17717235263 17717235263 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
上海珞珐生化科技有限公司021-51111890 15317326293 · [email protected]
BOC Sciences16314854226 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
成都标样生物科技有限公司028-81700200 13308200041 · [email protected]
上海策嵘生物科技有限公司(定制合成实验室)13917420128 13062833949 · [email protected]
上海立崎生物医学研究中心18014399201 · [email protected]
Shanghai Acmec Biochemical Technology Co., Ltd.+86-18621343501 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
医恩医疗系统研发(上海)有限公司021-58958002 18930822973 · [email protected]
陕西缔都医药化工有限公司029-88380327 17691182729 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
海蔚化学86-21-51086038 · [email protected]
爆牛贸易重庆有限公司+86-023-6139-8061 +86-86-13650506873 · [email protected]
河南奥创化工有限公司+86-0371-63689365 +8618638391208 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
上海迈瑞尔生化科技有限公司18621169109 · [email protected]
SHANGHAI KEAN TECHNOLOGY CO., LTD.+8613817748580 · [email protected]
上海贝万塔生物科技有限公司021-67187366 19901745723 · [email protected]
Additional notes · 1 item

DefinitionChEBI: Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine.