N-(2-Aminoethyl)piperidine (HCID 33944)

Names & identifiers

Preferred name: N-(2-Aminoethyl)piperidine
IUPAC: 2-piperidin-1-ylethanamine
English name: N-(2-Aminoethyl)piperidine
Molecular formula: C7H16N2
Molecular weight: 128.22

Names & synonyms

27578-60-5N-(2-AMINOETHYL)PIPERIDINE1-PiperidineethanamineEINECS 248-540-8AI3-11524DTXSID30181977NSC 54993RefChem:824985DTXCID70104468248-540-81-(2-Aminoethyl)piperidine2-(piperidin-1-yl)ethan-1-amine

Show more names

RARECHEM AL BW 0414LABOTEST-BB LT021006172-PiperidinoethanamineAMINO ETHYL PIPERIDINEN-AMINOETHYL PIPERIDINE1-PIPERIDINE ETHYLAMINE1-Piperidine ethanamine

2-piperidin-1-ylethanamine2-(piperidin-1-yl)ethanamine2-Piperidinoethylamine2-(1-Piperidinyl)ethanamineMFCD000065162-(1-Piperidinyl)ethylamine(2-Piperidin-1-ylethyl)amineN-Aminoethylpiperidine

Database identifiers

CAS: 27578-60-5
PubChem CID: 33944
DTXSID: DTXSID30181977
EC Number: 248-540-8
Nikkaji: J309C

Properties

Computed structural properties

XLogP: 0.4
Topological polar surface area: 29.3 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 2
Heavy atoms: 9
Formal charge: 0
Complexity: 67.3

Physicochemical properties

Melting point: 67 · 67-70 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
Boiling point: 186 °C · 186 °C(lit.)
Density: 0.899 g/mL · 0.899 g/mL at 25 °C(lit.)
refractive index: 20 · n20/D 1.473(lit.)
Flash point: 136 °F · 136 °F
storage temp.: 2 · under inert gas (nitrogen or Argon) at 2–8 °C
form: Liquid
pka: 1 · pK1: 6.38;pK2: 9.89 (30°C)
color: Clear colorless to yellow
Water Solubility: Partly miscible in water.
Sensitive: Air Sensitive
BRN: 103469 · 103469
InChI: InChI=1S/C7H16N2/c8-4-7-9-5-2-1-3-6-9/h1-8H2
InChIKey: CJNRGSHEMCMUOE-UHFFFAOYSA-N
SMILES: N1(CCN)CCCCC1
CAS DataBase Reference: 27578 · 27578-60-5(CAS DataBase Reference)
NIST Chemistry Reference: 1 · 1-Piperidineethanamine(27578-60-5)
UNSPSC Code: 12352100 · 12352100
Symbol(GHS): 2 · GHS02,GHS05
Signal word: Danger
Hazard statements: 226 · H226-H314
Precautionary statements: 210 · P210-P233-P240-P280-P303+P361+P353-P305+P351+P338
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C,Xi
Risk Statements: 34 · 34
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 2734 · UN 2734 8/PG 2
WGK Germany: 3 · 3
Hazard Note: Irritant
HazardClass: 3 · 3
PackingGroup: III
HS Code: 29333990 · 29333990
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 3 Skin · Flam. Liq. 3Skin Corr. 1B
Limited Quantities: 5 L · 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesFlam. Liq. 3 (100%)

Safety data

PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 3
ridadr: UN 2734 8/PG 2
hs_code: 29333990
risk_code: 34
Signal word: Danger
Symbol(GHS): GHS02,GHS05
hazard_code: C,Xi
hazard_note: Irritant
safety_code: 26-36/37/39-45
hazard_class: 3
Storage Class: 3 - Flammable liquids
packing_group: III
Hazard statements: H226-H314
Limited Quantities: 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Hazard Classifications: Flam. Liq. 3Skin Corr. 1B
Precautionary statements: P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

Chemistry & industry

Applications · 2 items

Uses1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

General Description1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.