Basic information
- CAS
25967-29-7- Standard SMILES
O=C1CN=C(c2ccccc2F)c2cc(Cl)ccc2N1CC1CC1- InChIKey
OFVXPDXXVSGEPX-UHFFFAOYSA-N- Molecular formula
- C19H16ClFN2O
- Average molar mass
- 342.8 g/mol
- Monoisotopic mass
- 342.093519
Overview
Flutoprazepam is an organic molecular entity.
Names & identifiers
- Preferred name
- Flutoprazepam
- IUPAC
- 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
- English name
- Flutoprazepam
- Molecular formula
- C19H16ClFN2O
- Molecular weight
- 342.79
Names & synonyms
flutoprazepamRestas25967-29-7FlutoprazepamumKB-5092GHY1101MMDTXSID201806317-Chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-oneRefChem:921732DTXCID601031227-Chloro-1-cyclopropylmethyl-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1,3-dihydro-
Show more names
KB-509PID-19372H-1,4-BENZODIAZEPIN-2-ONE7-Chloro-1-(cyclopropylMethyl)-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one7-Chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1，3-dihydro-2H-1，4-benzodiazepin-2-one
7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-Flutoprazepam (1.0mg/ml in Acetonitrile)Restar7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one7-Chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-oneFlutoprazepam [INN:JAN]Flutoprazepamum [INN-Latin]
Properties
Computed structural properties
- XLogP
- 3
- Topological polar surface area
- 32.7 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 521
Experimental & physicochemical properties
DrugsPharmaceuticals -> Nervous system -> Anxiolytics
Physicochemical properties
- Melting point
- 118 · 118-122°
- Boiling point
- 539.3 · 539.3±50.0 °C(Predicted)
- Density
- 1.2683 · 1.2683 (estimate)
- solubility
- 30 mg/ml; · DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 1.93 · 1.93±0.35(Predicted)
- FDA UNII
- 2 GHY1101MM · 2GHY1101MM
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302+H312+H332
- Precautionary statements
- 261 · P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501
- Toxicity
- 50 in · LD50 in male, female mice, rats (mg/kg): 2640, 2430, 13760, 10060 orally; 2400, 2110, 2460, 2230 i.p.; >5000 s.c. all species (Takebe)
Safety & regulation
Safety data
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 2640, 2430, 13760, 10060 orally; 2400, 2110, 2460, 2230 i.p.; >5000 s.c. all species (Takebe)
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302+H312+H332
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501
Chemistry & industry
Applications
DescriptionFlutoprazepam is a benzodiazepine anti-anxiety agent, somewhat longer acting and more potent than diazepam.
UsesFlutoprazepam, is a drug of a benzodiazepine class. It has shown to have muscle relaxant properties almost equivalent to Diazepam (D416855), however having more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects.
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: Flutoprazepam is an organic molecular entity.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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