Hydroxypropyl Methacrylate

1.06 at 68 °F (USCG, 1999) - Denser than water; will sink

1.066 @ 25 °C/16 °C

250 °F (USCG, 1999)

250 °F (open cup)

121 °C (Cleveland open cup)

Boiling point: 87 °C @ 0.67 kPa; Specific gravity: 1.028 @ 25 °C /2-Hydroxypropyl methacrylate/

Boiling point: 96 °C @ 1.3 kPa /2-Hydroxypropyl methacrylate/

Compound may polymerize when hot and burst container. May polymerize ... when exposed to ultraviolet light and free-radical catalysts.

METHYL METHACRYLATE, AND IN GENERAL THE METHACRYLIC ESTERS, POLYMERIZE MUCH LESS READILY THAN THE CORRESPONDING ORDINARY ACRYLATES. NONE THE LESS, THEY ARE STABILIZED BY ADDING HYDROQUINONE OR PYROGALLOL, PARTICULARLY IN THE PRESENCE OF METALLIC COPPER. /METHACRYLATES/

This chemical does not meet GHS hazard criteria for 0.8% (12 of 1419) of reports.

Warning

H317 (97%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1419 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Chemical: 2-Propenoic acid, 2-methyl-, 2-hydroxy-1-methylethyl ester

Chemical: 2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol

2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Methacrylic acid, monoester with propane-1,2-diol (EC: 248-666-3)

2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol: Does not have an individual approval but may be used under an appropriate group standard

Inhalation causes coughing and irritation of nose and throat; lung injury may occur. Ingestion causes irritation and burning of mouth and stomach. Contact of vapor with eyes causes irritation. Liquid may cause severe eye burns and irritation of skin. (USCG, 1999)

Allergic contact dermatitis reported in dental technicians; [Kanerva, p. 1743] An eye, nose, and throat irritant; [HSDB] May polymerize; A skin, eye, nose, and throat irritant; May cause injury to lungs and eyes; [CAMEO] May polymerize on exposure to light or heat; An irritant; May cause skin sensitization; [MSDSonline] See ACRYLIC RESINS (MONOMERS).

Skin Sens. 1 (97%)

Eye irritation - category 2A

Serious eye damage/eye irritation - Category 2

Temp during storage must be kept low to minimize formation of peroxides and other oxidation products. ... Storage temp below 30 °C are recommended for the polyfunctional methacrylates. ... The methacrylate monomers should not be stored for longer than one year. Shorter storage times are recommended for the aminomethacrylates, ie, three months, and the polyfunctional methacrylates, ie, six months. Many of these cmpd are sensitive to UV light and should, therefore, be stored in the dark. The methacrylic esters may be stored in mild steel, stainless steel, or aluminum. /Methacrylic acid & derivatives/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

... Hazard is the generation of considerable exothermic heat in some of the reactions, so that high pressures & temp may develop. This danger ... should be borne in mind when designing plant. Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Goggles or face shield; rubber gloves (USCG, 1999)

SUITABLE PROTECTIVE CLOTHING & SELF-CONTAINED RESP PROTECTIVE APPARATUS SHOULD BE AVAILABLE FOR USE OF THOSE WHO MAY HAVE TO RESCUE OF PERSONS OVERCOME BY FUMES. /ACRYLIC ACID & DERIVATIVES/

Goggles or face shield; rubber gloves.

Based on available data, the CIR Expert Panel concluded that ...Hydroxypropyl Methacrylate is safe as used in nail enhancement products when skin contact is avoided. Products containing these ingredients should be accompanied with directions to avoid skin contact, because of the sensitizing potential of Methacrylates.

Safe for use in cosmetics, with qualifications

Basic treatment: Establish a patent airway. Suction if necessary. Encourage patient to take deep breaths. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Irritating materials/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Irritating materials/

CIR ingredient: Hydroxypropyl Methacrylate

Used as monomer (i.e. acrylic resins, nonwoven fabric binders, and detergent lube oil additives) and in elastomers, laminating resins, and dental filling materials; [HSDB]

Textiles (Fiber & Fabric Manufacturing) [Category: Industry]

COMONOMER IN CROSS-LINKED-THERMOSET-ACRYLIC COATING RESINS; FOR ELASTOMERS, FOR LAMINATING RESINS; MONOMER FOR NONWOVEN FABRIC BINDER

IN DENTAL FILLING MATERIAL

Monomer for acrylic resins, detergent lube oil additives; nonwoven fabric binders

ADDITION OF PROPYLENE OXIDE TO METHACRYLIC ACID WITH A BASE AS CATALYST

Hydroxyalkyl methacrylates are prepared by the addition of methacrylic acid to the epoxide ring of alkylene oxides to form hydroxyalkyl methacrylates, ie, beta-hydroxyethyl and hydroxypropyl methacrylate. Oxides other than ethylene oxide give isomeric products; commercial hydroxypropyl methyacrylate has about a 2-to-1 ratio of 2-hydroxypropyl methacrylate to 1-methyl-2-hydroxyethyl methacrylate. Effective catalysts include tertiary amines, anion-exchange resins, ferric chloride, and lithium methacrylate.

The methacrylates can be synthesized by catalytic oxidation of isobutylene and subsequent esterification with the appropriate alcohol, or by reacting acetone with hydrocyanic acid and subsequent esterification in sulfuric acid with the appropriate alcohol. /Methacrylic esters/

Inhibitior of polymerization: 200 ppm hydroquinone

Grades of purity: Commercial, 95+%

Typical inhibitor level: 1200 ppm monomethyl ether hydroquinone

Electrical Equipment, Appliance, and Component Manufacturing

2-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol: ACTIVE

METHYL METHACRYLATE, AND IN GENERAL THE METHACRYLIC ESTERS, POLYMERIZE MUCH LESS READILY THAN THE CORRESPONDING ORDINARY ACRYLATES. NONE THE LESS, THEY ARE STABILIZED BY ADDING HYDROQUINONE OR PYROGALLOL, PARTICULARLY IN THE PRESENCE OF METALLIC COPPER. /METHACRYLATES/