Isooctyl Thioglycolate

0.9736 @ 25 °C

Density: 1.04 kg/l @ 20 °C

Clear, water-white liquid

Water-white liquid

Colorless or pale yellow liquid

125 °C @ 17 mm Hg

BP: 80-88 °C (6 kPa)

Liquid

Water-white liquid with a mild fruity odor; [Hawley] Colorless or pale yellow liquid; [HSDB] Clear white liquid; [Aldrich MSDS]

Warning

H302 (85.3%): Harmful if swallowed [Warning Acute toxicity, oral]；H317 (84.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (14.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H400 (84.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (51.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]；H412 (15.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 258 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Acetic acid, mercapto-, isooctyl ester

Acetic acid, 2-mercapto-, isooctyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-mercapto-, isooctyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 04-09-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/1906

Acetic acid, mercapto-, isooctyl ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Causes hypotension in rats and rabbits (IV administration); Emergency treatment: Thioglycolates; The highly alkaline thioglycolates cause both irritant and allergic contact dermatitis in hairdressers; [HSDB] Classified by European Commission as not irritating; Not sensitizing in guinea pig maximization test; [IUCLID] May cause irritation; [Aldrich MSDS] See Glyceryl monothioglycolate.

Acute Tox. 4 (85.3%)；Skin Sens. 1 (84.9%)；Eye Irrit. 2 (14.7%)；Aquatic Acute 1 (84.9%)；Aquatic Chronic 1 (51.6%)；Aquatic Chronic 3 (15.1%)

Acute toxicity - category 4；Skin sensitisation - category 1

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Based on the available data, the CIR Expert Panel concluded that ... Isooctyl Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure.

Safe for use in cosmetics, with qualifications

In a subchronic toxicity study, male and female day old Leghorn chicks (5/sex/group) were exposed to isooctyl mercaptoacetate (as a 10% solution in corn oil) once daily for 14 consecutive days. Dose levels of 0.10, 0.18, 0.25, 0.28, and 0.50 ml/kg resulted in the deaths of 0, 1, 2, 5, and 10 birds, respectively (the table reporting the sex of the victims was not included on the document fiche). The LD1 is 0.13 (0.07 to 0.23) ml/kg, the LD50 is 0.28 (0.22 to 0.35) ml/kg, and the LD99 is 0.58 ml/kg (0.33 to 1.0) ml/kg. Several of the birds which died during the study exhibited a loss of equilibrium on the day preceding death; otherwise the chicks appeared normal throughout the study. No statistically significant differences were observed in the final body weights between any of the groups except the highest-dose level group for which no final average weight was obtained due to 100% mortality. Since no gross pathological abnormalities were observed in any of the birds, no histopathological examinations were conducted.

BLOOD PRESSURE EFFECT STUDIED IN RABBITS, RATS, & DOGS FOLLOWING IV ADMIN. THIOGLYCOLIC ACID WAS HYPOTENSIVE IN RATS & RABBITS. THIS WAS MORE PRONOUNCED WITH ISOOCTYL THIOGLYCOLATE & EVEN MORE WITH 2-ETHYLHEXANOL. ALL ARE POTENTIALLY FATAL & AFFECT RESP & HEART RATE.

Chemical: Acetic acid, mercapto-, isooctyl ester

Acetic acid, 2-mercapto-, isooctyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-mercapto-, isooctyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 04-09-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/1906

Acetic acid, mercapto-, isooctyl ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

CIR ingredient: Isooctyl Thioglycolate

Used in antioxidants, fungicides, oil additives, plasticizers, insecticides, stabilizers, and polymerization modifiers; Also used as a stabilizer (tin-sulfur compounds) and stripping agent (polysulfide rubber); [Hawley]

Farming (Pesticides) [Category: Industry]

Antioxidants, fungicides, oil additives, plasticizers, insecticides, stabilizers, polymerization modifiers, stabilizer in tin-sulfur compounds, stripping agent for polysulfide rubber.

Grade: 99% (min purity)

Sold water free.

All Other Chemical Product and Preparation Manufacturing

Acetic acid, 2-mercapto-, isooctyl ester: ACTIVE

Esters of thioglycolic acid are to a large extent manufactured by conventional esterification processes. Manufacture at a larger scale of ... isooctyl thioglycolate by a continuous process gives esters of higher consistency.