Bromuconazole

LD50 Anas platyrhynchos (Mallard duck) oral >2150 mg/kg[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on 1-[

LC50 Anas platyrhynchos (Mallard duck) diet >5000 ppm/8 days[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on 1-[

LC50 Colinus virginianus (Bobwhtie quail) diet >5000 ppm/8 days[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on 1-[

LD50 Colinus virginianus (Bobwhite quail) oral >2150 mg/kg[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on 1-[

For more Ecotoxicity Values (Complete) data for BROMUCONAZOLE (14 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1380(SRC), determined from a log Kow of 3.24(2) and a regression-derived equation(3), indicates that bromomuconazole is expected to have low mobility in soil(SRC). Volatilization of bromomuconazole from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 8.2X10-11 atm-cu m/mole(SRC) derived from its vapor pressure, 3X10-8 mm Hg(2), and water solubility, 50 mg/L(2). Bromomuconazole is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Biodegradation data were not available (SRC, 2005).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1380(SRC), determined from a log Kow of 3.24(2) and a regression-derived equation(3), indicates that bromomuconazole is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) to be an important fate process(SRC) given a Henry's Law constant of 8.2X10-11 atm-cu m/mole(SRC) derived from its vapor pressure, 3X10-8 mm Hg(2), and water solubility, 50 mg/L(2). According to a classification scheme(4), an estimated BCF of 62(SRC), from its log Kow(2) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegrdation data were not available(SRC, 2005).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromomuconazole, which has a vapor pressure of 3X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase bromomuconazole may be removed from the air by wet and dry deposition(SRC). Under simulated sunlight degradation of bromuconazole is pH dependent. Bromuconazole had a reported half-life of 18 days under acidic conditions(2).

The Koc of bromomuconazole is estimated as 1380(SRC), using a log Kow of 3.24(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromomuconazole is expected to have low mobility in soil.

An estimated BCF of 62 was calculated for bromomuconazole(SRC), using a log Kow of 3.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for bromomuconazole is estimated as 8.2X10-11 atm-cu m/mole(SRC) derived from its vapor pressure, 3X10-8 mm Hg(1), and water solubility, 50 mg/L (1). This Henry's Law constant indicates that bromomuconazole is expected to be essentially nonvolatile from moist soil and water surfaces(2). Bromomuconazole is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Acute Exposure/ Non-irritating to eyes and skin of rabbits. Non-sensitising to skin of guinea pigs.[Tomlin CDS, ed. Bromuconazole (116255-48-2). In: The e-Pesticide Manual, 13th Edition Version 3.2 (2005-06). Surrey UK, British Crop Protection Council.]

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Rats /were administered/ 0, 40, 200, 1000, or 5000 ppm via the diet /for thirteen weeks/. NOAEL: 200 ppm (M: 13.8 mg/kg/day; F: 15.1 mg/kg/day) LOAEL: 1000 ppm (M: 68.1 mg/kg/day; F: 74.5 mg/kg/day) based on decreased body weight gains in females, changes in hematology/blood chemistry parameters and in the incidence of microscopic lesions consistent with liver toxicity, and increased liver weight gain in both sexes.[USEPA/Office of Prevention Pesticides and Toxic Substances; Pesticide Fact Sheet on Bromuconazole. Available from, as of July 13, 2006: http://www.epa.gov/opprd001/factsheets/bromuconazole.pdf]

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Rats were dosed at 20, 150, 1000, 2000 ppm in the diet; NOAEL: 20 ppm (0.88 mg/kg/day); LOAEL: 150 ppm (6.48 mg/kg/day) based on non-neoplastic lesions; Not oncogenic under the conditions of the study.[USEPA/Office of Prevention Pesticides and Toxic Substances; Pesticide Fact Sheet on Bromuconazole. Available from, as of July 13, 2006: http://www.epa.gov/opprd001/factsheets/bromuconazole.pdf]

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Mice were dosed at 0, 100, 1000, and 3000 ppm in the diet. NOAEL 100 ppm (M:12.3 mg/kg/day; F: 10.9 mg/kg/day); LOAEL 1000 ppm (F:134.5 mg/kg/day) based on decreased body weight gains.[USEPA/Office of Prevention Pesticides and Toxic Substances; Pesticide Fact Sheet on Bromuconazole. Available from, as of July 13, 2006: http://www.epa.gov/opprd001/factsheets/bromuconazole.pdf]

For more Non-Human Toxicity Excerpts (Complete) data for BROMUCONAZOLE (13 total), please visit the HSDB record page.

Bromomuconazole is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). Bromuconazole is susceptible to photolysis(SRC). This reaction is enhanced under acidic conditions; a photolysis half-life for bromomuconazole of 18 days under acidic conditions has been reported(2).

Bromomuconazole's production may result in its release to the environment through various waste streams; its use as an agricultural fungicide will result in its direct release to the environment. If released to air, a vapor pressure of 3X10-8 mm Hg at 25 °C indicates bromomuconazole will exist solely in the particulate phase in the atmosphere. Particulate-phase bromomuconazole will be removed from the atmosphere by wet and dry deposition. Bromuconazole is susceptible to pH dependent photolysis. A photolysis half-life of 18 days has been reported for bromuconazole under acidic conditions. If released to soil, bromomuconazole is expected to have low mobility based upon an estimated Koc of 1380. Volatilization from water and moist soil surfaces is not expected to be an important fate process based upon a Henry's Law constant of 8.2X10-11 atm-cu m/mole. Bromomuconazole is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, bromomuconazole is expected to adsorb to suspended solids and sediment based upon the estimated Koc. An estimated BCF of 62 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to bromomuconazole may occur through dermal contact with this compound at workplaces where bromomuconazole is produced or used. (SRC)