Basic information
- CAS
546-89-4- Standard SMILES
CC(=O)[O-].[Li+]- InChIKey
XIXADJRWDQXREU-UHFFFAOYSA-M- Molecular formula
- C2H3LiO2
- Average molar mass
- 66 g/mol
- Monoisotopic mass
- 66.02930889
Overview
Lithium acetate is an acetate salt comprising equal numbers of acetate and lithium ions. It is an organic lithium salt and an acetate salt. It contains an acetate.
Names & identifiers
- Preferred name
- Lithium acetate
- IUPAC
- lithium acetate
- English name
- Lithium acetate
- Molecular formula
- C2H3LiO2
- Molecular weight
- 65.99
Names & synonyms
Lithium acetate546-89-4Lithium ethanateQuiloneQuilonormACETIC ACID, LITHIUM SALTCHEBI:63045Acetic acid, lithium salt (1:1)H4278O5FLVDTXSID00883436RefChem:153690DTXCID501022967
Show more names
Lithiumacetatithium acetatelithiumethanateLithiumethanoatlithiumethanoateLithiumAcetate>Acetic acid lithiumLithium acetate, pure
208-914-3lithium;acetatelithiumacetateAcOLilithium ethanoateAcetic acid lithium saltLiOAcCH3COOLi
Database identifiers
- CAS
546-89-4- PubChem CID
- 3474584
- DTXSID
DTXSID00883436- ChEBI
CHEBI:63045- UNII
- H4278O5FLV
- EC Number
- 208-914-3
- Nikkaji
- J423E
Properties
Computed structural properties
- Topological polar surface area
- 40.1 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 5
- Formal charge
- 0
- Complexity
- 34.6
Experimental & physicochemical properties
Chemical ClassesMetals -> Organic Acids, Metal Salts
Density1.28 @ 20°C
Melting Point280 °C
Physical Description
Other Solid
Solid; Becomes dihydrate at 56.5 deg C; [Merck Index] White powder; Soluble in water; [MSDSonline]
Physicochemical properties
- Melting point
- 283 · 283-285 °C (lit.)
- Density
- 1.3 · 1.3[at 20℃]
- vapor pressure
- 0 Pa · 0Pa at 25℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 2 O: · H2O: 5 M at 20 °C, clear, colorless
- form
- Powder or Crystals
- color
- White to yellow
- Water Solubility
- 40.8 g/100 · 40.8 g/100 mL (20 ºC)
- Merck
- 14 · 14,5521
- Stability
- Stable. Incompatible with strong oxidizing agents.
- Major Application
- battery precursorscatalystsmaterial synthesis precursor
- InChI
- InChI=1S/C2H4O2.Li/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- InChIKey
- XIXADJRWDQXREU-UHFFFAOYSA-M
- SMILES
- C([O-])(=O)C.[Li+]
- LogP
- 0.09 at · 0.09 at 25℃
- CAS DataBase Reference
- 546 · 546-89-4(CAS DataBase Reference)
- FDA UNII
- 4278 O5FLV · H4278O5FLV
- EPA Substance Registry System
- Lithium acetate (546-89-4)
- UNSPSC Code
- 12352103 · 12352103
- NACRES
- 23 · NA.23
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H319
- Precautionary statements
- 264 · P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36
- Safety Statements
- 23 · 23-24/25-39-26-22
- WGK Germany
- 1 · 1
- RTECS
- 5450000 · AI5450000
- TSCA
- TSCA listed
- HS Code
- 29152990 · 29152990
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 4 OralEye · Acute Tox. 4 OralEye Irrit. 2
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 29.7% (102 of 343) of reports.
Warning
H302 (64.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 343 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Acetic acid, lithium salt
Acetic acid, lithium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, lithium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 13-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/21532
Acetic acid, lithium salt: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Acetic acid, lithium salt: Human health tier I assessment
Hazards SummaryMay cause irritation; Affects the central nervous system when used as a drug; [MSDSonline] See Lithium.
Hazard Classes and CategoriesAcute Tox. 4 (64.7%)
Safety & protection
Exposure Control and Personal Protection0.2 [mg/m3], inhalable fraction, as Li[German Research Foundation (DFG)]
Protective Action Criteria (PAC)
3.2 [mg/m3]
36 [mg/m3]
210 [mg/m3]
Toxicology
Adverse EffectsNeurotoxin - Other CNS neurotoxin
Safety data
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- AI5450000
- hs_code
- 29152990
- risk_code
- 36
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 23-24/25-39-26-22
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H319
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2
- Precautionary statements
- P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Chemistry & industry
Uses & manufacturing
UsesUsed as an anti-manic drug; [Merck Index] Used to produce drugs and polyesters; [Ullmann]
U.S. Production2023: <50,000 lb
Consumer UsesDye
Industry UsesDye
General Manufacturing Information
Paper Manufacturing
Acetic acid, lithium salt (1:1): ACTIVE
Applications
DescriptionLithium acetate (CH3COOLi) is a salt of lithium and acetic acid.
UsesLithium acetate is used in the laboratory as buffer for gel electrophoresis of DNA and RNA. It has a lower electrical conductivity and can be run at higher speeds than can gels made from TAE buffer (5-30V/cm as compared to 5 - 10 V / cm). Lithium boric acid or sodium boric acid are usually preferable to lithium acetate or TAE when analyzing smaller fragments of DNA (less than 500 bp) due to the higher resolution of borate-based buffers in this size range as compared to acetate buffers. Lithium acetate is also used to permeabilize the cell wall of yeast for use in DNA transformation. It is believed that the beneficial effect of LiAc is caused by its chaotropic effect denaturing both DNA, RNA and proteins.
UsesLithium acetate hydrate is used in the laboratory as buffer for gel electrophoresis of DNA and RNA. It is also used to permeabilize the cell wall of yeast for use in DNA transformation. It is a metal acetate for proteomics research.
UsesLithium acetate (LiOAc) is a lithium source and a doping salt which can be used in the preparation of plasticized polymer electrolytes for lithium-ion batteries. It can be used as a monovalent cation, which improves the transformation efficiency of Saccharomyces cerevisiae.
Upstream & downstream products
Upstream raw materials
Downstream products
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上海仪化科技有限公司18017215653 · [email protected]
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Additional notes
DefinitionChEBI: An acetate salt comprising equal numbers of acetate and lithium ions.
Related reactions
62 records
Compound notes
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