Basic information
- CAS
1176637-26-5- Standard SMILES
CCN(CC)C(=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCc2ccccc2)[C@H](O)C[C@@H]1O- InChIKey
CDQCYBXRNLOTSU-JATUTAOYSA-N- Molecular formula
- C27H41NO4
- Average molar mass
- 443.6 g/mol
- Monoisotopic mass
- 443.30355879
Names & identifiers
- Preferred name
- 17-phenyl trinor Prostaglandin F2alpha diethyl amide
- IUPAC
- (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N,N-diethylhept-5-enamide
- English name
- 17-phenyl trinor Prostaglandin F2α diethyl amide
- Molecular formula
- C27H41NO4
- Molecular weight
- 443.62
Names & synonyms
1176637-26-517-phenyl trinor Prostaglandin F2alpha diethyl amideN-Ethyl BimatoprostBimatoprost diethylamide(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N,N-diethylhept-5-enamideBimatoprost diethyl amideBimatoprost Impurity X17-Phenyl trinor prostaglandin F2|A diethyl amideBimatoprost Impurity 24orb2283577C27H41NO4CDQCYBXRNLOTSU-JATUTAOYSA-N
Show more names
17-phenyl trinor Prostaglandin F2α diethyl amide5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N,N-diethyl-, (5Z)-
DTXSID901372697HMS3648J16MFCD03412002HY-W746888T84653SR-01000946518SR-01000946518-117-Phenyl- trinor-prostaglandin F2.alpha. diethyl amide
Database identifiers
- CAS
1176637-26-5- PubChem CID
- 35023844
- DTXSID
DTXSID901372697
Properties
Computed structural properties
- XLogP
- 3.4
- Topological polar surface area
- 81 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 13
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 580
Physicochemical properties
- Boiling point
- 610.4 · 610.4±55.0 °C(Predicted)
- Density
- 1.125 · 1.125±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 30 mg/ml; · DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
- pka
- 14.25 · 14.25±0.20(Predicted)
- Symbol(GHS)
- 2 · GHS02,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- 225 · H225-H319-H360-H336
- Precautionary statements
- 201 · P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS07,GHS08
- Hazard statements
- H225-H319-H360-H336
- Precautionary statements
- P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
Chemistry & industry
Applications
Description17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 2.5 μg/g corneal tissue/hr.3 However, dialkyl amides such as 17-phenyl trinor PGF2α diethyl amide are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.
Uses17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF2α analog with hypotensive efficacy[1].
Suppliers3 total
上海宏叶生物科技有限公司400-9205774 400-920-5774 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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