Basic information
- CAS
14325-05-4- Standard SMILES
C=CC1=C(C)C2=Cc3c(C=C)c(C)c4[n]3[Sn][n]3c(c(C)c(CCC(=O)O)c3=CC3=NC(=C4)C(C)=C3CCC(=O)O)=CC1=N2- InChIKey
YFPCUOXWZGYBEL-UHFFFAOYSA-L- Molecular formula
- C34H32N4O4Sn
- Average molar mass
- 679.4 g/mol
- Monoisotopic mass
- 680.144558
Names & identifiers
- Preferred name
- 3-[20-(2-Carboxyethyl)-9,14-bis(ethenyl)-5,10,15,19-tetramethyl-2,22,23,25-tetraza-1-stannaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3(24),4,6,8,10,12,14,16,18,20-decaen-4-yl]propanoic acid
- IUPAC
- 3-[20-(2-carboxyethyl)-10,15-bis(ethenyl)-5,9,14,19-tetramethyl-21,23,24,25-tetraza-22λ2-stannahexacyclo[9.9.3.13,6.113,16.08,23.018,21]pentacosa-1,3(25),4,6,8,10,12,14,16(24),17,19-undecaen-4-yl]propanoic acid
- English name
- TIN PROTOPORPHYRIN IX DICHLORIDE
- Molecular formula
- C34H36Cl2N4O4Sn
- Molecular weight
- 754.29
Names & synonyms
3-[20-(2-Carboxyethyl)-9,14-bis(ethenyl)-5,10,15,19-tetramethyl-2,22,23,25-tetraza-1-stannaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3(24),4,6,8,10,12,14,16,18,20-decaen-4-yl]propanoic acidNSC267099MS-33257SnPPIXTINPROTOPORPHYRINTin protoporphyrin Itin protoporphyrin IXTIN PROTOPORPHYRIN IX DICHLORIDETin Protoporphyrin IX (chloride)Tinprotoporphyrin IX,Tin protoporphyrin IXTin Protoporphyrin IX dichloride (NSC 267099Purine nucleoside phosphorylase, Microorganism
Database identifiers
- CAS
14325-05-4- PubChem CID
- 3545604
Properties
Computed structural properties
- Topological polar surface area
- 107 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 8
- Heavy atoms
- 43
- Formal charge
- 0
- Complexity
- 1,660
Physicochemical properties
- storage temp.
- Store at RT
- solubility
- 25 mM · Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO
- form
- Dark red to violet solid.
- color
- Brown to reddish brown
- FDA UNII
- 3 JT9G2P · DIO3JT9G2P
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H315-H335
- Precautionary statements
- 264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H319-H315-H335
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Chemistry & industry
Applications
UsesTin Protoporphyrin IX Dichloride is a selective inhibitor of heme oxygenase.
UsesHeme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]
Suppliers43 total
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Aladdin Scientific[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海道鞅科技有限公司QQ:3150471267 13381681725 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
Related reactions
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Compound notes
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