Basic information
- CAS
777-11-7- Standard SMILES
Clc1cc(Cl)c(OCC#CI)cc1Cl- InChIKey
CTETYYAZBPJBHE-UHFFFAOYSA-N- Molecular formula
- C9H4Cl3IO
- Average molar mass
- 361.4 g/mol
- Monoisotopic mass
- 359.83725
Overview
Haloprogin is an aromatic ether.
Names & identifiers
- Preferred name
- Haloprogin
- IUPAC
- 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene
- English name
- HALOPROGIN
- Molecular formula
- C9H4Cl3IO
- Molecular weight
- 361.39
Names & synonyms
haloprogin777-11-7HalotexMycandenMycilanPolikHaloprogineHaloproginaM-1028 (Meiji)HaloproginumNSC-1000713-Iodo-2-propynyl 2,4,5-trichlorophenyl ether
Show more names
m1028FungaclorHALOPROGIN (200 MG)
DTXSID9046865AIU7053OWL1,2,4-Trichloro-5-((3-iodoprop-2-yn-1-yl)oxy)benzeneM-10281,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzeneBenzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)-NSC100071DTXCID7026865
Database identifiers
- CAS
777-11-7- PubChem CID
- 3561
- DTXSID
DTXSID9046865- ChEMBL
CHEMBL1289- ChEBI
CHEBI:5614- UNII
- AIU7053OWL
- EC Number
- 212-286-6
- Nikkaji
- J3.326J
Properties
Computed structural properties
- XLogP
- 4.6
- Topological polar surface area
- 9.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 2
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 247
Experimental & physicochemical properties
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Listed in ZINC15
LogP5.3
Solubility6.01e-03 g/L
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Melting Point
114-115
113.5 °C
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 113 · 113-114°
- Boiling point
- 477.49 °C · 477.49°C (rough estimate)
- Density
- 1.935 · 1.9350 (estimate)
- form
- Solid
- color
- White to off-white
- FDA UNII
- 7053 OWL · AIU7053OWL
- ATC code
- 1 AE11 · D01AE11
- Hazard Codes
- Xn
- Risk Statements
- 22 · 22-36/37/38
- Safety Statements
- 26 · 26-36
- RTECS
- 1225000 · KO1225000
- Toxicity
- 50 in · LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesEye Irrit. 2 (100%)
Safety data
- rtecs
- KO1225000
- Toxicity
- LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)
- risk_code
- 22-36/37/38
- hazard_code
- Xn
- safety_code
- 26-36
Chemistry & industry
Pharmacology
ATC Code
D - Dermatologicals
QD - Dermatologicals
Pharmacodynamics
Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Mechanism of Action
Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals.
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Cellular LocationsMembrane
Applications
UsesHaloprogin is a topical antifungal agent used in the treatment of dermatophytic and monilial infections.
UsesAntibacterial.
General Description3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.
Upstream & downstream products
Upstream raw materials
Suppliers19 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Shanghai Scibiotron Pharmaceutical Co., Ltd+86-16621589600 · [email protected]
上海昶衍化工科技有限公司021-20242659 18930833303 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
杭州六可生物科技有限公司+86-0571-86912261 +86-15658003402 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海鑫矽新材料有限公司13585834793 13660927110 · [email protected]
河北贞佳新材料有限公司0319-5925599 13315915972 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
上海琼燕医药科技有限公司086-021-15821262312 15821262312 · [email protected]
陕西缔都医药化工有限公司029-029-029-81148696 18161915376 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD.13817489192 · [email protected]
重庆卡兰医药有限公司[email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]
Additional notes
DefinitionChEBI: Haloprogin is an aromatic ether.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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