Basic information
- CAS
69301-27-5- Standard SMILES
CC(C)=CCC[C@@H](C)c1ccc(C)cc1O- InChIKey
BTXSROVNGICYFE-CYBMUJFWSA-N- Molecular formula
- C15H22O
- Average molar mass
- 218.33 g/mol
- Monoisotopic mass
- 218.16706532
Overview
5-Methyl-2-(6-methylhept-5-en-2-yl)phenol has been reported in Callicarpa japonica, Antillogorgia rigida, and other organisms with data available.
Names & identifiers
- Preferred name
- Curcuphenol
- IUPAC
- 5-methyl-2-[(2R)-6-methylhept-5-en-2-yl]phenol
- English name
- Phenol, 2-(1,5-dimethyl-4-hexenyl)-5-methyl-
- Molecular weight
- 0
Names & synonyms
Curcuphenol69301-27-5RefChem:9192855-methyl-2-[(2R)-6-methylhept-5-en-2-yl]phenol(R)-5-Methyl-2-(6-methylhept-5-en-2-yl)phenolorb1703574SCHEMBL29571282SCHEMBL31545696DTXSID20989025NSC622273AKOS040745686NSC-622273
Show more names
CS-0068600T23919Phenol, 2-(1,5-dimethyl-4-hexenyl)-5-methyl-2-[(1R)-1,5-dimethylhex-4-enyl]-5-methyl-phenol
Database identifiers
- CAS
69301-27-5- PubChem CID
- 360253
- DTXSID
DTXSID20989025- Nikkaji
- J18.660K
Properties
Computed structural properties
- XLogP
- 5.3
- Topological polar surface area
- 20.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 4
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 228
Chemistry & industry
Applications
DescriptionCurcuphenol in concentrations in the range of 29-116 μg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. Findings suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
UsesCurcuphenol is a compound with histone deacetylase enhancing activity and has the activity of reversing immune escape. Curcuphenol can reverse the immune escape of tumors by restoring the expression of antigen presentation machinery. Its two synthetic analogs have histone deacetylase enhancing activity and play an important role in the immune recognition of metastatic tumors.
Suppliers4 total
河南闰霖化工有限公司+86-18738066252; +86-18738066252 · [email protected]
Shanghai Scibiotron Pharmaceutical Co., Ltd+86-16621589600 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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