Basic information
- CAS
32672-69-8- Standard SMILES
CN1CCCCC1CCN1c2ccccc2Sc2ccc(S(C)=O)cc21.O=S(=O)(O)c1ccccc1- InChIKey
CRJHBCPQHRVYBS-UHFFFAOYSA-N- Molecular formula
- C27H32N2O4S3
- Average molar mass
- 544.8 g/mol
- Monoisotopic mass
- 544.15242103
Overview
Mesoridazine besylate is the benzenesulfonate salt of mesoridazine prepared using equimolar amounts of mesoridazine and benzenesulfonic acid. It has a role as a dopaminergic antagonist and a first generation antipsychotic. It contains a mesoridazine.
Names & identifiers
- Preferred name
- Mesoridazine Besylate
- IUPAC
- benzenesulfonic acid;10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfinylphenothiazine
- English name
- Mesoridazine Besylate
- Molecular formula
- C27H32N2O4S3
- Molecular weight
- 544.75
Names & synonyms
MESORIDAZINE BESYLATE32672-69-8Mesoridazine benzenesulfonatemesoridazine besilateNC 12310-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine benzenesulfonateNSC-760073UNII-T4G2I958J2T4G2I958J2Mesoridazine besylate (USP)Mesoridazine besylate [USP]10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine monobenzenesulfonate
Show more names
nc123SERENTILMesoridazine Besylate (250 mg)Mesoridazine Besylate (1393005)Mesoridazine Besilate (10-[2-[(2RS)Mesoridazine Besylate, 10 mM in DMSOylsulfinyl)ethyl)-10h-phenothiazine(1:1)Mesoridazine benzenesulfonate|||Serentil
CHEBI:6781mesoridazine monobenzenesulfonatethioridazine-2-sulfoxide besylate(+-)-10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine monobenzenesulfonateNSC 76007310H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-, (+-)-, monobenzenesulfonateMESORIDAZINE BESILATE (MART.)MESORIDAZINE BESILATE [MART.]
Properties
Computed structural properties
- Topological polar surface area
- 131 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 5
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 686
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 174 · 174-175 °C
- storage temp.
- 2 · 2-8°C
- solubility
- 10 mg/mL · DMSO: 10 mg/mL
- form
- solid
- color
- white
- Stability
- Hygroscopic
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- CRJHBCPQHRVYBS-UHFFFAOYSA-N
- SMILES
- OS(=O)(=O)c1ccccc1.CN2CCCCC2CCN3c4ccccc4Sc5ccc(cc35)S(C)=O
- FDA UNII
- 4 G2I958J2 · T4G2I958J2
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 7 · GHS07
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Other Safety InformationIMAP assessments - Benzenesulfonic acid, compound with 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine (1:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Mesoridazine besylate
Ambiguous-DILI-concern
5
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Safety data
- wgk
- 3
- rtecs
- DB7176700
- hs_code
- 2934302300
- Toxicity
- LD50 in mice (mg/kg): 33 i.v.; 611 s.c.; 346 orally (Maruyama)
- risk_code
- 22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
Chemistry & industry
Applications
UsesMesoridazine (M225755) Besylate is an antipsychotic.
Usesantpsychotic
General DescriptionMesoridazine besylate,10-[2-(methyl-2-piperidyl)ethyl]-2-(methylsulfinyl)phenothiazinemonobenzenesulfonate (Serentil), shares manyproperties with thioridazine. However, no pigmentaryretinopathy has been reported.
Upstream & downstream products
Upstream raw materials
Suppliers26 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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