1-(Cyclopropylmethyl)-6-methoxy-4-phenyl-2(1H)-quinazolinone
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Basic information
- CAS
33453-23-5- Standard SMILES
COc1ccc2c(c1)c(-c1ccccc1)nc(=O)n2CC1CC1- InChIKey
VAFNJIFAZJWWNI-UHFFFAOYSA-N- Molecular formula
- C19H18N2O2
- Average molar mass
- 306.4 g/mol
- Monoisotopic mass
- 306.13682782
Overview
Ciproquazone is a small molecule drug. The usage of the INN stem '-azone' in the name indicates that Ciproquazone is a anti-inflammatory analgesic, phenylbutazone derivative. Ciproquazone has a monoisotopic molecular weight of 306.14 Da.
Names & identifiers
- Preferred name
- 1-(Cyclopropylmethyl)-6-methoxy-4-phenyl-2(1H)-quinazolinone
- IUPAC
- 1-(cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2-one
- English name
- Ciproquazone
- Molecular formula
- C19H18N2O2
- Molecular weight
- 306.36
Names & synonyms
CIPROQUAZONE33453-23-5CiproquazonumciprocuazonaSL-573P8S0GE5Q4I1-(Cyclopropylmethyl)-6-methoxy-4-phenyl-2(1H)-quinazolinoneDTXSID401871021-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinoneRefChem:126329DTXCID10109593Ciproquazone [INN]
Show more names
Cyproquazone1-Cyclopropylmethyl-6-methoxy-4-phenyl-2(1H)-quinazolinone1-(Cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2(1H)-one
1-(cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2-oneCiproquazonaCiproquazonum [INN-Latin]Ciproquazona [INN-Spanish]SL 573UNII-P8S0GE5Q4IBRN 07615922(1H)-Quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl-
Database identifiers
- CAS
33453-23-5- PubChem CID
- 36489
- DTXSID
DTXSID40187102- ChEMBL
Properties
Computed structural propertiesFilling in
- XLogP
- 2.5
- Topological polar surface area
- 41.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 480
Physicochemical properties
- Melting point
- 115 · 115-116 °C(Solv: ethyl acetate (141-78-6))
- Boiling point
- 483.8 · 483.8±47.0 °C(Predicted)
- Density
- 1.26 · 1.26±0.1 g/cm3(Predicted)
- pka
- 0.28 · 0.28±0.20(Predicted)
- FDA UNII
- 8 S0GE5Q4I · P8S0GE5Q4I
Chemistry & industry
Applications
UsesCiproquazone (SL-573) is a compound that inhibits prostaglandin biosynthesis. Its relative inhibitory potency is between that of indomethacin and aspirin, and its inhibition of prostaglandin biosynthesis is reversible.
Related reactions
1 records
Compound notes
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