Basic information
- CAS
14918-35-5- Standard SMILES
CNC1CC(N)C(O)C(OC2OC(CO)C(O)C3OC4(OC(C(N)CO)C(O)C(O)C4O)OC23)C1O- InChIKey
GRRNUXAQVGOGFE-UHFFFAOYSA-N- Molecular formula
- C20H37N3O13
- Average molar mass
- 527.5 g/mol
- Monoisotopic mass
- 527.23263824
Overview
Destomysin is an amino cyclitol.
Names & identifiers
- Preferred name
- Destomysin
- IUPAC
- 4-[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
- English name
- destomycin A
- Molecular formula
- C20H37N3O13
- Molecular weight
- 527.52
Names & synonyms
DestomysinHygrovetineHygrovectineHyanthelmixHygromycinBC20H37N3O13Hygromycin B from Streptomyces hygroscopicusCHEBI:4454SCHEMBL18763320D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1.fwdarw.2-3)-O-.beta.-D-talopyranosyl-(1.fwdarw.5)-2-deoxy-N1-methyl-s29084-[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
Show more names
DestoMycinDESTONATEDestonate 20destomycin ADestonmycin A5)-2-deoxy-N1-methyl-destomycin A USP/EP/BP2-3)-O-b-D-talopyranosyl-(1®D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1®D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N1-methyl-
CID 23777801DB-068433Hygromycin B from Streptomyces hygroscopicus powderQ271063884-[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexoxy]-6'-(1-amino-2-hydroxy-ethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-tetrahydropyran]-3',4',5',7-tetrolD-Stretamine,3-O-[6-(1-amino-2-hydroxyethyl)tetrahydro-3,4,5-trihydroxy-2H-pyran-2-ylidene)-.beta.-D-talopyranosyl]-2-deoxy-N(sup3)methyl-
Database identifiers
- CAS
14918-35-5、31282-04-9- PubChem CID
- 3659
- ChEBI
CHEBI:4454
Properties
Computed structural properties
- XLogP
- -6.6
- Topological polar surface area
- 272 Ų
- Hydrogen bond donors
- 11
- Hydrogen bond acceptors
- 16
- Rotatable bonds
- 6
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 756
Experimental & physicochemical properties
Melting Point160 - 180 °C
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 180 · 180-190° (dec)
- alpha
- 22 · D22 +7° (c = 2)
- Boiling point
- 608.13 °C · 608.13°C (rough estimate)
- Density
- 1.4252 · 1.4252 (rough estimate)
- refractive index
- 1.63 · 1.6300 (estimate)
- pka
- 12.53 · 12.53±0.10(Predicted)
- CAS DataBase Reference
- 14918 · 14918-35-5
- FDA UNII
- 7443 WI4A · PL7443WI4A
- Toxicity
- 50 in · LD50 in mice (after 2-week observation) (mg/kg): 5-10 i.v.; 50-100 orally (Kondo, 1965)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in mice (after 2-week observation) (mg/kg): 5-10 i.v.; 50-100 orally (Kondo, 1965)
Chemistry & industry
Pharmacology
Cellular LocationsCytoplasm
Applications
DescriptionDestomycin A was found in the culture broth of Streptomyces rimofaciens by Meiji Seika Kaisha in 1965 in the course of screening for water-soluble and basic antibiotics, such as aminoglycosides. It shows activity against a variety of gram-positive and gram-negative bacteria as well as fungi and, more interestingly, against helminths. Destomycin A has been used to treat helminth infections in swine and poultry.
UsesDemycin A is currently mainly used in feed to prevent and control digestive tract parasites in chickens and pigs.
Upstream & downstream products
Upstream raw materials
Suppliers14 total
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd+86-13119157289 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
郑州安步防护用具有限公司+86-0371-88006763; +86-15988602810 · [email protected]
上海倍卓生物科技有限公司021-61119791,13386096464 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +86-15355479329 · [email protected]
广州和为医药科技有限公司17612033329 17612033329 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
湖北万业众诚化学试剂有限责任公司18671296875 · [email protected]
南京罗迈美生物科技有限公司[email protected]
武汉研哲科技有限公司15527250409 · [email protected]
career henan chemical co+86-0371-86658258 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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