Isopropalin

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

Avoid breathing spray mist or eye, skin, clothing contact. Keep away from children.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Notice revokes the tolerances for the residues of the herbicide isopropalin in or on the raw agricultural commodities peppers and tomatoes, removing section 180.313 from tne CFR. Related food uses were voluntarily cancelled by the registrant before 1982.

Isopropalin

Hematologic

1.5 x 10 ^-2 mg/kg-day

Isopropalin was incorporated in soil, and tomato and pepper seeds were planted in some of the plots. Tobacco transplants were placed in other plots. After all were harvested, wheat was sown and harvested the following year. Analyses of soil and plants involved TLC, column chromatography, GC-MS and thin-layer radioautography. In soil, in addition to bound and unidentified compounds, nine metabolites were identified in addition to unchanged isopropalin: 2,6-dinitro-N-propylcumidine, 2,6-dinitro-cumidine, 2-amino-N,N-dipropylamino-6-nitrocumidine, 2-amino-6-nitro-N-propylcumidine, 2-ethyl-5-isopropyl-7-nitro-1-propylbenzimidazole, 4'-isopropyl-2',6'-dinitro-N-propylpropionanilide, 4'-isopropyl-2',6'-dinitropropionanilide, and alpha, alpha-dimethyl-3,5-dinitro-4-dipropylaminobenzyl alcohol. Negligible amounts of isopropalin or its degradation products were found in the plants grown on treated soil.

0.015

IRIS Current

0.15

HEAST Current

LD50 Rabbit percutaneous >2000 mg/kg

LD50 Rat oral >5000 mg/kg

1.20e+03

1.80e+04

4.00e+01

5.00e+01

9.20e-01

1.50e-02

3.50e+03

5.30e+04

1.20e+02

5.00e+01

1.50e-02

Volatile

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Isopropalin is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0005; Pesticide type: herbicide; Registration Standard Date: 08/01/81; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Isopropalin; Data Call-in (DCI) Date(s): 08/20/90; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Notice revokes the tolerances for the residues of the herbicide isopropalin in or on the raw agricultural commodities peppers and tomatoes, removing section 180.313 from the CFR. Related food uses were voluntarily cancelled by the registrant before 1982.