Isoproturon

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ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

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Effects of three photosystem II inhibitors and of their mixture on a freshwater phytoplankton community were studied in outdoor mesocosms. Atrazine, isoproturon, and diuron were applied as 30% hazardous concentrations (HC30s) obtained from species-sensitivity distributions. Taking concentration addition into account, the mixture comprised one-third of the HC30 of each substance. Effects were investigated during a five-week period of constant concentrations and a five-month posttreatment period when the herbicides dissipated. Total abundance, species composition, and diversity and recovery of the community were evaluated. Ordination techniques, such as principal component analysis and principal response curve, were applied to compare the various treatments on the community level. The three herbicides stimulated comparable effects on total abundance and diversity of phytoplankton during the period of constant exposure because of the susceptibility of the dominant cryptophytes Chroomonas acuta and Cryptomonas erosa et ovata and the prasinophyte Nephroselmis cf. olivacea. Moreover, concentration addition described combined effects of atrazine, isoproturon, and diuron on total abundance and diversity in the constant-exposure period, because their mixture induced effects on abundance and diversity similar to those of the single substances. Principal component and principal response curve analyses revealed that the community structure of diuron- and isoproturon-treated phytoplankton recovered two weeks after constant exposure, which might be related to the fast dissipation of the phenylureas. Species compositions of mixture- and atrazine-treated communities were not comparable to that of the control community five months after the end of constant exposure. This might be explained by the slower dissipation of atrazine relative to the phenylureas and by differences in the species sensitivities, resulting in a different succession of phytoplankton.

Rats were treated orally with technical hexachlorocyclohexane (HCH, 12.5, 25 and 50 mg/kg/day) and technical isoproturon (ISP 22.5. 45 and 90 mg/kg/day) daily for a period of 90 days alone and in combination. Treatment with HCH alone showed mild to severe toxicity and death. Significant changes occurred in liver weight, clinical enzyme profiles, hematological parameters and pathomorphological changes. Treatment with ISP alone did not produce such changes. The combination of HCH and ISP produced changes not suggestive of synergism.

The cytogenetic effects of deltamethrin (DEL) and/or isoproturon (ISO) were examined in human lymphocytes and mouse bone marrow cells. Peripheral lymphocytes were exposed to DEL (2.5, 5, 10, or 20 uM), ISO (25, 50, 100, or 200 uM), or DEL + ISO (2.5 + 25, 5 + 50, 10 + 100, or 20 + 200 uM) and cytogenic effects were evaluated via chromosomal aberrations (CA) and the cytokinesis-block micronucleus assay (CBMN). Mice were orally gavaged to single dose of DEL (6.6 mg/kg), ISO (670 mg/kg), or DEL+ISO (6.6 + 670 mg/kg) for 24 hr or to DEL (3.3 mg/kg/day), ISO (330 mg/kg/day), or DEL + ISO (3.3 + 330 mg/kg/day) for 30 days and analyzed for CA. DEL induced a significant frequency of CA at 10 uM whereas ISO (25-100 uM) alone, or in combination with DEL, did not show any significant effect. Micronucleus (MN) induction was observed to be concentration-dependent though significant frequencies were observed at 5 uM DEL, 100 uM ISO, or 5 + 50 uM DEL + ISO. In mice, DEL inhibited the mitotic index (MI) significantly (P < 0.001) at 24 hr while ISO alone, or in combination with DEL, did not cause any statistically significant effect. Following a 24 hr exposure, DEL and ISO alone induced significant (P < 0.01) frequencies of CA, whereas DEL + ISO in combination did not. Furthermore, 30 days exposure of ISO significantly inhibited the MI (P < 0.02 or < 0.01) and induced CA while DEL alone, or in combination with ISO, resulted in no significant effect on CA or the MI. The present findings indicate that the in vitro and in vivo exposure of a commercial formulation of DEL can cause genotoxic effects in mammals. However, the coexposure of DEL and ISO did not show additive effects, but instead demonstrated somewhat reduced genotoxicity.

Here, we assess the physiological effects induced by environmental concentrations of pesticides in Pacific oyster Crassostrea gigas. Oysters were exposed for 14 d to trace levels of metconazole (0.2 and 2 ug/L), isoproturon (0.1 and 1 ug/L), or both in a mixture (0.2 and 0.1 ug/L, respectively). Exposure to trace levels of pesticides had no effect on the filtration rate, growth, and energy reserves of oysters. However, oysters exposed to metconazole and isoproturon showed an overactivation of the sensing-kinase AMP-activated protein kinase alpha (AMPKalpha), a key enzyme involved in energy metabolism and more particularly glycolysis. In the meantime, these exposed oysters showed a decrease in hexokinase and pyruvate kinase activities, whereas 2-DE proteomic revealed that fructose-1,6-bisphosphatase (F-1,6-BP), a key enzyme of gluconeogenesis, was up-regulated. Activities of antioxidant enzymes were higher in oysters exposed to the highest pesticide concentrations. Both pesticides enhanced the superoxide dismutase activity of oysters. Isoproturon enhanced catalase activity, and metconazole enhanced peroxiredoxin activity. Overall, our results show that environmental concentrations of metconazole or isoproturon induced subtle changes in the energy and antioxidant metabolisms of oysters.

For more Interactions (Complete) data for Isoproturon (8 total), please visit the HSDB record page.

EC50; Species: Desmodesmus subspicatus (Green Algae) 10000 cells/mL, CCAP 276/22; Conditions: freshwater, static, 23 °C; Concentration: 27 ug/L for 72 hr; Effect: population, decreased abundance /99.9% purity/

EC50; Species: Parachlorella kessleri (Green Algae) 10000 cells/mL; Conditions: freshwater, static, 23 °C; Concentration: 54 ug/L for 72 hr; Effect: population, decreased abundance /99.9% purity/

EC50; Species: Desmodesmus subspicatus (Green Algae) exponential growth phase (log), inoculated with 10000 cells/mL; Conditions: freshwater, static, 23 °C, pH 8; Concentration: 149 ug/L for 72 hr; Effect: population, decreased population growth rate

EC50; Species: Chlorella pyrenoidosa (Green Algae) 60000 cells/mL; Conditions: freshwater, static, 25 °C; Concentration: 5 ug/L for 96 hr; Effect: population, decreased population growth rate /95% purity/

For more Ecotoxicity Values (Complete) data for Isoproturon (18 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 126(2) indicates that isoproturon is expected to have moderate mobility in soil(SRC). Volatilization of isoproturon from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-9 atm-cu m/mole(SRC), based upon its vapor pressure, 2.47X10-8 mm Hg(3), and water solubility, 65 mg/L(3). Isoproturon is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Laboratory studies have shown that 14C-labeled isoproturon is 5-25% mineralized to CO2 within 2-3 months at 20 °C(8) indicating that biodegradation is not an important environmental fate process in soil(SRC).

FIELD STUDIES: Isoproturon may persist in soil. Field studies indicate a slow natural degradation rate of isoproturon following agricultural practices with leaching losses after rain events. Leaching to underlying aquifers may occur for at least 3 years following application(1).

AQUATIC FATE: Based on a classification scheme(1), a Koc value of 126(2) indicates that isoproturon is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.9X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 2.47X10-8 mm Hg(4), and water solubility, 65 mg/L(4). According to a classification scheme(6), a BCF of 40(SRC), from its log Kow of 2.87(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Laboratory studies have shown that 14C-labeled isoproturon is 5-25% mineralized to CO2 within 2-3 months at 20 °C(8) indicating that biodegradation is not an important environmental fate process in water(SRC).

ECOSYSTEM: Approximately 9% of applied C14-labelled isoproturon (5.07 ug/L) was removed from three fresh water microcosms operated for 21 days simulating outdoor conditions with a 12 hour photoperiod at 23 °C. Volatilization was very low at 0.13% of the applied isoproturon. A BCF of 15.8 was measured in Lemna minor (duckweed). Mineralization was reported at 0.49% applied over 21 days(1).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isoproturon, which has a vapor pressure of 2.47X10-8 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase isoproturon is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.3 days(SRC), calculated from its rate constant of 1.20X10-11 cu cm/molecule-sec at 25 °C(3). Particulate-phase isoproturon may be removed from the air by wet and dry deposition(SRC). Isoproturon absorbs UV light at 245 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight since sunlight consists of wavelengths above 290 nm(SRC).

IDENTIFICATION AND USE: Isoproturon is a solid. It was formerly used in the United States as pre- and post-emergence herbicide for control of annual grasses and broad-leaved weeds. HUMAN STUDIES: Micronucleus induction was observed in human lymphocytes exposed to 100 uM isoproturon. ANIMAL STUDIES: Repeated applications of isoproturon technical (IPT) and its wettable powder formulation (IPF) to the skin of male and female rats for 21 days caused mild to moderate toxic effects. IPT was more toxic to male rats as evidenced by animal mortality and enzymatic and hematological changes. The toxicity of IPF was less to both sexes. In adult male rats exposed to isoproturon, testis showed degeneration and desquamation of cells of germinal layers. Tubular lumens of testis and epididymis exhibited reduced number of spermatids and spermatozoa, respectively, indicating retardation of spermatogenesis. Effect of isoproturon (0.225, 0.45 and 0.90 g/kg/day) administered from day 6 through 15 of gestation was studied on pregnant rats and their offspring. There were no distinct clinical signs other than dose-related depression and drowsiness of pregnant rats. At higher doses, decreased maternal body weight was observed during the advanced stage of pregnancy. The litter size, fetal weight and crown-rump and transumbilical lengths were decreased. There was an increase in fetal resorption frequency and the number of fetuses with stunted growth. The genotoxic effect of isoproturon was assessed by employing in vivo chromosomal aberration, micronucleus and sperm-shape abnormality assays. A significant dose-responsive mutagenic effect was observed in chromosome aberration and sperm-shape abnormality tests whereas in micronucleus assay the effect was significant only at the highest dose (200 mg/kg). ECOTOXICITY STUDIES: Cellular volume and dry weight of Chlorella vulgaris cells were increased strongly in the presence of isoproturon. Isoproturon was found to be nontoxic to bees. In earthworm (Lumbricus terrestris), no lethal effect of isoproturon was observed even at the highest concentration tested (1.4 g/kg soil) after 60 days after treatment. The use of the growth rate of earthworms was proposed as biomarker of exposure to isoproturon. In Allium sativum, exposure to isoproturon induced root growth retardation and morphological changes like discoloration and stiffness of roots. Exposure to various experimental concentrations of isoproturon (35-280 ppm) significantly and dose-dependently inhibited the mitotic index and induced chromosome breaks/mitotic aberrations at 6 or 24 hr.

/AQUATIC SPECIES/ Herbicide concentrations fluctuate in rivers following crop application and can reach high levels after rain events, yet the duration of these pulses is short. In the present study, we assessed the effect of atrazine and isoproturon pulse exposure on Scenedesmus vacuolatus (Chlorophyceae; strain 211-8b, Kessler) as well as the recovery in the postexposure period. We further explored whether the time-dependent toxicity is similar for herbicides inhibiting the photosystem II (PSII). The growth rate was assessed for different exposure durations, and in addition the inhibition of the effective quantum yield of PSII was measured to monitor the response at the target site. Atrazine and isoproturon did not have similar time-dependent effects on growth rate, despite their same primary mode of action on PSII. Atrazine was less toxic than isoproturon after 10 hr of exposure, but the toxicity of both herbicides was similar after 48 hr of exposure. However, both compounds inhibited the PSII effective quantum yield within 1 hr following exposure. Similarly, the effective quantum yield recovered completely within 4 hr after removal of the toxicants, leading to rapid recovery of algal growth. The rapid onset of effects of isoproturon on the growth of the alga during exposure suggests that a single pulse to this herbicide is likely to induce greater effects than an atrazine pulse at the same concentration, even if these effects are reversible. The information gained in the present study should support the effect assessment of sequential exposures as well as the risk evaluation of fluctuating herbicidal exposure.

/AQUATIC SPECIES/ Effects of three photosystem II inhibitors and of their mixture on a freshwater phytoplankton community were studied in outdoor mesocosms. Atrazine, isoproturon, and diuron were applied as 30% hazardous concentrations (HC30s) obtained from species-sensitivity distributions. Taking concentration addition into account, the mixture comprised one-third of the HC30 of each substance. Effects were investigated during a five-week period of constant concentrations and a five-month posttreatment period when the herbicides dissipated. Total abundance, species composition, and diversity and recovery of the community were evaluated. Ordination techniques, such as principal component analysis and principal response curve, were applied to compare the various treatments on the community level. The three herbicides stimulated comparable effects on total abundance and diversity of phytoplankton during the period of constant exposure because of the susceptibility of the dominant cryptophytes Chroomonas acuta and Cryptomonas erosa et ovata and the prasinophyte Nephroselmis cf. olivacea. Moreover, concentration addition described combined effects of atrazine, isoproturon, and diuron on total abundance and diversity in the constant-exposure period, because their mixture induced effects on abundance and diversity similar to those of the single substances. Principal component and principal response curve analyses revealed that the community structure of diuron- and isoproturon-treated phytoplankton recovered two weeks after constant exposure, which might be related to the fast dissipation of the phenylureas. Species compositions of mixture- and atrazine-treated communities were not comparable to that of the control community five months after the end of constant exposure. This might be explained by the slower dissipation of atrazine relative to the phenylureas and by differences in the species sensitivities, resulting in a different succession of phytoplankton.

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Isoproturon was detected in 51% of 90 European wastewater treatment plant effluents sampled in 2010. The average concentration was 10.1 ng/L (max 270 ng/L) and limit of quantitation = 1 ng/L(1). Isoproturon was detected in the dissolved and particulate phases on all 38 storm water runoff sites located in Paris, France and its suburbs following 15 storm events. The concentration range was <0.1 to 0.14 ug/L; median of 0.03 ug/L. Isoproturon is one of the most widely used herbicides in urban settings and, therefore, its presence in the watershed is ubiquitous(2).

Pesticide residues are frequently found in water bodies and may threaten freshwater ecosystems and biodiversity. In addition to runoff or leaching from treated agricultural fields, pesticides may enter streams via effluents from wastewater treatment plants (WWTPs). We compared the pesticide toxicity in terms of log maximum Toxic Unit (log mTU) of sampling sites in small agricultural streams of Germany with and without WWTPs in the upstream catchments. We found an approximately half log unit higher pesticide toxicity for sampling sites with WWTPs (p < 0.001). Compared to fungicides and insecticides, herbicides contributed most to the total pesticide toxicity in streams with WWTPs. A few compounds (diuron, terbuthylazin, isoproturon, terbutryn and Metazachlor) dominated the herbicide toxicity. Pesticide toxicity was not correlated with upstream distance to WWTP (Spearman's rank correlation, rho = - 0.11, p > 0.05) suggesting that other context variables are more important to explain WWTP-driven pesticide toxicity. Our results suggest that WWTPs contribute to pesticide toxicity in German streams.

A log Koc 2.1 (Koc 126) for isoproturon has been reported(1). According to a classification scheme(2), this Koc value suggests that isoproturon is expected to have moderate mobility in soil(SRC). Freundlich constants ranging from 2.1-5.3 mg/kg were reported using 13 different cultivated soils from Lorraine, France and Brittany(3). Isoproturon sorbs to organic colloids in solution with the establishment of a threshhold. Below that threshhold, isoproturon appears to sorb predominantly to clays(4). Adsorption of isoproturon to soils takes place in three phases: dissolved in solution; bound to insoluble matter; adsorbed to organic colloids in suspenstion(5). An average Freundlich adsorption coefficient of 15 was reported after 6 hrs using 10 ug isoproturon/L and activated sludge from a German WWTP. The log Koc value is 1.5 for treatment in the nitrification zone(8), corresponding to a Koc in sludge of 32(SRC). Predicted treatment plant removal is <5%(6).

Isoproturon Freundlich constants of in 13 French soils; concentration = 1 mg/L(1).[Table#6181]

/GENOTOXICITY/ The alkaline comet assay was used to assess DNA damage in mononuclear leukocytes of farmers before and after a 1-day spraying period with selected pesticides under usual conditions. Two blood samples were collected, one in the morning of the day of spraying (S0) and the second in the morning of the day after (S1). Here, we assessed variations in DNA damage levels between these two sampling times. Four groups of farmers were formed, according to exposure to: (a) various fungicide-insecticide mixtures (including chlorothalonil; group 1, n = 8), (b) the herbicide isoproturon (group 2, n = 11), (c) fungicide triazoles (group 3, n = 14), and (d) a fungicide (chlorothalonil)-insecticide mixture (group 4, n = 8). An increase in DNA damage levels was observed at S1 for groups 1 and 4, who were exposed to similar pesticides. This increase was correlated with area sprayed between S0 and S1 and with the number of spraying tanks used over this 1-day period. No effect was observed on cell viability or on hematological parameters for these two groups. No statistically significant modification of DNA damage level was observed the day after spraying for groups 2 and 3, when each was observed as a whole. However, some farmers presented significantly more DNA damage after exposure, and others presented less damage. In these two groups, a significant decrease of neutrophils was observed at S1, and a decrease of red blood cells was observed in group 3. In parallel, a significant loss of lymphocyte viability was observed in these two groups. A 1-day spraying period seems to be sufficient to significantly modify DNA damage levels in mononuclear leukocytes, but the correlation of this change with pesticide-related exposure parameters depends on the kind of pesticide concerned.

/GENOTOXICITY/ The cytogenetic effects of deltamethrin (DEL) and/or isoproturon (ISO) were examined in human lymphocytes and mouse bone marrow cells. Peripheral lymphocytes were exposed to DEL (2.5, 5, 10, or 20 uM), ISO (25, 50, 100, or 200 uM), or DEL + ISO (2.5 + 25, 5 + 50, 10 + 100, or 20 + 200 uM) and cytogenic effects were evaluated via chromosomal aberrations (CA) and the cytokinesis-block micronucleus assay (CBMN). Mice were orally gavaged to single dose of DEL (6.6 mg/kg), ISO (670 mg/kg), or DEL+ISO (6.6 + 670 mg/kg) for 24 hr or to DEL (3.3 mg/kg/day), ISO (330 mg/kg/day), or DEL + ISO (3.3 + 330 mg/kg/day) for 30 days and analyzed for CA. DEL induced a significant frequency of CA at 10 uM whereas ISO (25-100 uM) alone, or in combination with DEL, did not show any significant effect. Micronucleus (MN) induction was observed to be concentration-dependent though significant frequencies were observed at 5 uM DEL, 100 uM ISO, or 5 + 50 uM DEL + ISO. In mice, DEL inhibited the mitotic index (MI) significantly (P < 0.001) at 24 hr while ISO alone, or in combination with DEL, did not cause any statistically significant effect. Following a 24 hr exposure, DEL and ISO alone induced significant (P < 0.01) frequencies of CA, whereas DEL + ISO in combination did not. Furthermore, 30 days exposure of ISO significantly inhibited the MI (P < 0.02 or < 0.01) and induced CA while DEL alone, or in combination with ISO, resulted in no significant effect on CA or the MI. The present findings indicate that the in vitro and in vivo exposure of a commercial formulation of DEL can cause genotoxic effects in mammals. However, the coexposure of DEL and ISO did not show additive effects, but instead demonstrated somewhat reduced genotoxicity.

Isoproturon's production may result in its release to the environment through various waste streams; it's use as a pre- and post-emergence herbicide(1) will result in its direct release to the environment(SRC). It is not marketed in the US(2).

AEROBIC: Laboratory studies have shown that 14C-labeled isoproturon is 5-25% mineralized to CO2 within 2-3 months at 20 °C. Isoproturon binding to soil components greatly decreases the mineralization of the phenyl ring making it less available to microbial processes. A concentration of 1.25 mg/kg of 14C-labelled isoproturon was 6% mineralized to CO2 within 20 days when incubated for 135 days in agricultural soil from fields in Graese and Flakkebjerg, Denmark previously exposed for nine and one year, respectively, to isproturon. Isoproturon was degraded abiotically to 3-(4-isopropylphenyl)-1-methyl urea, 3-(4-isopropylphenyl)-urea and 4-isopropylaniline. Field studies indicate a slow natural degradation rate of isoproturon following agricultural practices with leaching losses after rain events(1).

ANAEROBIC: No mineralization was reported for isoproturon incubated anaerobically in the presence of nitrate using a sandy aquifer sediment microcosm. Isoproturon was not mineralized after incubation for 310 days at 10 °C using aquifer sediments under denitrifying, sulfate-reducing or methanogenic conditions(1).

PURE CULTURE: The rate at which two Shingomonas sp. mineralized C14-labeled isoproturon was affected by the pH of the liquid medium; faster rates were observed at increasing pH in the range of 6.5-7.5(1).

PURE CULTURE: Isoproturon (IPU) degradation in an agricultural soil inoculated with an isolated IPU-degrader strain (Sphingomonas sp. strain AK1, IS) or a microbial consortium (MC) harboring this strain, with or without carrier material, were investigated in soil microcosm experiments during 46 days. Effect of the carrier material and inoculation size on IPU-degradation efficacy of the inoculants were studied. Mineralization, extractable residues and non-extractable residues of 14C-labeled IPU were analyzed. The low IPU mineralization in untreated soil (7.0%) was enhanced to different extents by inoculation of IS (17.4%-46.0%) or MC (58.9%-67.5%). Concentrations of IPU residues in soils amended with MC (0.002-0.095 ug/g dry soil) were significantly lower than in soils amended with IS (0.02-0.67 ug/g dry soil) and approximately 10 times lower than in the uninoculated soil (0.06-0.80 ug/g dry soil). Less extractable residues and non-extractable residues were detected in soil with higher IPU mineralization. Inoculation size (as indicated by the volume of liquid cultures or by the number of carrier particles) determined the IPU-removal efficacy of IS in soil, but this effect was less pronounced for MC. The low sorption of IPU to soil and the decreasing IPU-mineralizing rates suggested incapability of IS to establish the IPU-mineralizing function in the soil. The thorough removal of IPU and persistent IPU-mineralizing activity of soil inoculated with MC indicated a high persistence of IPU-metabolic trait. Our results showed that microbial consortia might be more efficient than single degrader strains to enhance clean-up of organic chemicals in soil.

An estimated BCF of 40 was calculated in fish for isoproturon(SRC), using a log Kow of 2.87(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

For isoproturon (USEPA/OPP Pesticide Code: 512200) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Pre- and post-emergence herbicide for control of annual grasses and broad-leaved weeds.

Herbicide

Isoproturon is produced by reaction of 4-isopropylphenyl isocyanate with dimethylamine.

Preparation ...: C. W. Todd, United States of America patent 2655447 (1953 to du Pont); Belgium patent 770928 (1971 to Pepro); A. Thizy et al., United States of America patent 4295877 (1981 to Philagro).

Trade Names. Panron, Alon, Arelon, Strong, Passport, Trump, Ingot Javelin Gold.

Dispersion, flowable, water dispersible granule, wettable powder.

Premix Partners: Beflubutamid; Bifenox; Bromoxynil; Chlorotoluron; Diflufenican; Dinoterb; Fenoxaprop-P-ethyl; Fluoroglycofen-ethyl; Flurtamone; Ioxynil; Mecoprop; Mecoprop-P; Metribuzin; Neburon; Orbencarb; Simazine; Triasulfuron.

Pharmaceuticals

Herbicides

Environmental transformation -> Pesticides (parent, predecessor)

Pesticides -> Herbicides -> Urea herbicides -> Phenylurea herbicides

Registration Notes: USA: Not marketed. Outside USA: Zodiac TX in France.

The WHO Recommended Classification of Pesticides by Hazard identifies isoproturon (technical grade) as Class II: moderately hazardous; Main Use: herbicide.

... isoproturon has the same mode of action and similar applications as diuron. However, it is far less used in practice.