Completing data — usually done within a minute
Basic information
- CAS
34183-22-7- Standard SMILES
CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1.Cl- InChIKey
XWIHRGFIPXWGEF-UHFFFAOYSA-N- Molecular formula
- C21H28ClNO3
- Average molar mass
- 377.9 g/mol
- Monoisotopic mass
- 377.17577144
Overview
Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Names & identifiers
- Preferred name
- Propafenone Hydrochloride
- IUPAC
- 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
Names & synonyms
PROPAFENONE HYDROCHLORIDE34183-22-7Propafenone HClRythmol SRBaxarytmonPropafenon hydrochlorid1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride33XCH0HOCD1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochlorideNSC-7586401-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone hydrochloride
Show more names
Hydrochloride, Propafenone1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, hydrochlorideCHEBI:8466DTXSID1010172332'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone HydrochlorideRefChem:55925DTXCID7014754251-(2-((2RS)-2-Hydroxy-3-(propylamino)propyloxy)phenyl)-3-phenylpropan-1-one monohydrochloride
Database identifiers
- CAS
34183-22-7- PubChem CID
- 36708
- DTXSID
DTXSID101017233- ChEMBL
CHEMBL1201063- ChEBI
CHEBI:8466- UNII
- 33XCH0HOCD
- EC Number
- 251-867-9
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 58.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 11
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 368
Experimental & physicochemical properties
Solubility>56.7 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section177.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Safety & regulation
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 154 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Propafenone hydrochloride
vLess-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
PROPAFENONE HYDROCHLORIDE
Antiarrhythmic [EPC]
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
Related reactions
1 records
Compound notes
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