Basic information
- CAS
85753-43-1- Standard SMILES
O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21- InChIKey
MEXUTNIFSHFQRG-UHFFFAOYSA-N- Molecular formula
- C20H13N3O
- Average molar mass
- 311.3 g/mol
- Monoisotopic mass
- 311.10586204
Overview
K-252c is an indolocarbazole.
Names & identifiers
- Preferred name
- K-252C
- IUPAC
- 3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one
- English name
- K-252C
- Molecular formula
- C20H13N3O
- Molecular weight
- 311.34
Names & synonyms
K-252cK252CRefChem:792611632-917-285753-43-1staurosporinone6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-oneHAJ5XS5HPFK-252c; StaurosporinoneSTAUROSPORINE AGLYCONCHEMBL169586,7,12,13-Tetrahydro-5H-indolo-[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Show more names
StaurosporonineSTAUROSPORINE AGLYCONEK-252c(Staurosporinone)Staurosporinone, K-252cK252c, Ready Made SolutionStaurosporine Aglycone >99%K-252c - CAS 85753-43-1 - Calbiochem
SD-18253,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one5H-Indolo(2,3-a)pyrrolo(3,4-C)carbazol-5-one, 6,7,12,13-tetrahydro-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 6,7,12,13-tetrahydro-6,7,12,13-Tetrahydro-5H-indolo(2,3-a)pyrrolo(3,4-C)carbazol-5-oneUNII-HAJ5XS5HPFCBiol_002017BDBM2581
Database identifiers
- CAS
85753-43-1- PubChem CID
- 3815
- DTXSID
DTXSID801017989- ChEMBL
CHEMBL16958、CHEMBL268368- ChEBI
CHEBI:204201- UNII
- HAJ5XS5HPF
- EC Number
- 632-917-2
- Nikkaji
- J462.137I
Properties
Computed structural properties
- XLogP
- 3.7
- Topological polar surface area
- 60.7 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 551
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 200 °C · >200°C (dec.)
- storage temp.
- 20 °C · −20°C
- solubility
- 10 mg/mL, · DMSO: 10 mg/mL, soluble
- form
- solid
- color
- Pale Brown to Light Brown
- Water Solubility
- 25 mM · Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.
- InChI
- InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
- InChIKey
- MEXUTNIFSHFQRG-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C2=C1C1NC3=C(C=1C1CNC(=O)C=12)C=CC=C3
- FDA UNII
- 5 XS5HPF · HAJ5XS5HPF
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H319
- Precautionary statements
- 264 · P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
- Safety Statements
- 22 · 22-24/25
- RIDADR
- 1993 · NA 1993 / PGIII
- WGK Germany
- 3 · 3
- HS Code
- 29333990 · 29333990
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 4 OralEye · Acute Tox. 4 OralEye Irrit. 2
Safety & regulation
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- ridadr
- NA 1993 / PGIII
- hs_code
- 29333990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H319
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2
- Precautionary statements
- P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Chemistry & industry
Applications
UsesInhibits protein kinase C
Upstream & downstream products
Upstream raw materials
Suppliers42 total
上海美洛英特化学有限公司15821661757 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
苏州景皓生物科技有限公司18136139868; 18136139868
上海炎泽化工有限公司15345144255 19975051755 · [email protected]
广州佳途科技股份有限公司81960175 18933936954 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
湖北瑞玛标物科技有限公司15787879035 15787875101 · [email protected]
Aladdin Scientific[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
VDM Biochemicals0330-2528181 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
无锡捷化医药科技有限公司83588313 18800520310 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
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上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
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Capot Chemical Co.,Ltd.+86-（0）57185586718 +86-13336195806 · [email protected]
江苏艾康生物医药研发有限公司025-58859352 19370895928 · [email protected]
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Hefei Hirisun Pharmatech Co., Ltd+8615056975894 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海陌孚医药科技有限公司4000862158 18117107507 · [email protected]
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Coresyn Pharmatech Co., Ltd.+86-571-86626709 +86-18157142896 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海佰世凯生物科技有限公司021-20908456 · [email protected]
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上海传芊化工科技中心15869524721 · [email protected]
南京世洲生物科技有限公司025-85560043 13675144456 · [email protected]
Related reactions
1 records
Compound notes
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