Basic information
- CAS
40507-23-1- Standard SMILES
Cc1ccc2c(-c3ccc(F)cc3)nc(=O)n(C(C)C)c2c1- InChIKey
ZWOUXWWGKJBAHQ-UHFFFAOYSA-N- Molecular formula
- C18H17FN2O
- Average molar mass
- 296.3 g/mol
- Monoisotopic mass
- 296.13249133
Overview
structure given in first source
Names & identifiers
- Preferred name
- Fluproquazone
- IUPAC
- 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
- English name
- Fluproquazone
- Molecular formula
- C18H17FN2O
- Molecular weight
- 296.343
Names & synonyms
FluproquazoneTormosyl40507-23-1FluproquazonumFluprocuazonaU4K85O58HD4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinoneDTXSID701935194-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone4-(p-fluorophenyl)-1-isopropyl-7-methyl-quinazolin-2(1H)-oneRefChem:921724DTXCID60116010
Show more names
46-790RF-46-7904-(4-Fluorophenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one
4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinoneRF 46-790;SaH 46-790;Tormosyl2(1H)-Quinazolinone, 4-(4-fluorophenyl)-7-methyl-1-(1-methylethyl)-FluproquazonaFluproquazonum [INN-Latin]Fluproquazona [INN-Spanish]RF 46-790
Database identifiers
- CAS
40507-23-1- PubChem CID
- 38503
- DTXSID
DTXSID70193519- ChEMBL
CHEMBL2106681
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 32.7 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 454
Physicochemical properties
- Melting point
- 172 · 172-174°
- Density
- 1.1845 · 1.1845 (estimate)
- FDA UNII
- 4 K85O58HD · U4K85O58HD
- Toxicity
- 50 in · LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Applications
UsesAnalgesic.
Suppliers4 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
2 records
Compound notes
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