Basic information
- CAS
2379-57-9- Standard SMILES
O=c1[nH]c2cc([N+](=O)[O-])c([N+](=O)[O-])cc2[nH]c1=O- InChIKey
RWVIMCIPOAXUDG-UHFFFAOYSA-N- Molecular formula
- C8H4N4O6
- Average molar mass
- 252.14 g/mol
- Monoisotopic mass
- 252.01308386
Overview
6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione is a quinoxaline derivative.
Names & identifiers
- Preferred name
- Dnqx
- IUPAC
- 6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione
- English name
- DNQX
- Molecular formula
- C8H4N4O6
- Molecular weight
- 252.14
Names & synonyms
dnqx2379-57-9FG-9041FG 90412,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-62T278S1MX6,7-dinitro-1,2,3,4-tetrahydroquinoxaline-2,3-dioneRefChem:5991826,7-dinitro-1,4-dihydroquinoxaline-2,3-dione6,7-Dinitroquinoxaline-2,3(1H,4H)-dione6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione6,7-dinitro-2,3-quinoxalinediol
Show more names
DNQX DISODIUM SALTDNXQFG-904fg9041DNQX,98%D0540-50MGDNQX, 10 mM in DMSO7-Dinitroquinoxaline-2DNQX, AMPA / kainate antagonist
MFCD000692571,4-Dihydro-6,7-Dinitro-2,3-QuinoxalinedioneBiomol-NT_000182Lopac0_000345HMS3261E11Tox21_500345SDCCGSBI-0050333.P002NCGC00015319-03
Database identifiers
- CAS
2379-57-9- PubChem CID
- 3899541
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 150 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 0
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 386
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesChemical shift
Physicochemical properties
- Melting point
- 300 °C · >300°C
- Boiling point
- 395.32 °C · 395.32°C (rough estimate)
- Density
- 1.6919 · 1.6919 (rough estimate)
- refractive index
- 1.67 · 1.6700 (estimate)
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- Soluble in DMSO
- form
- Pale yellow solid.
- pka
- 7.68 · 7.68±0.20(Predicted)
- color
- Off-White to Light Yellow
- Water Solubility
- 2 O: · H2O: 100mM
- Stability
- -20 °C · Store in freezer at -20°C
Safety & regulation
Safety data
- wgk
- 3
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H301+H311+H331
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P312-P361+P364-P403+P233-P405-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationDrugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Applications
UsesPotent competitive non-NMDA glutamate receptor antagonist
UsesDNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.
Upstream & downstream products
Upstream raw materials
Suppliers65 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…