Basic information
- CAS
53714-56-0- Standard SMILES
CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1- InChIKey
GFIJNRVAKGFPGQ-UHFFFAOYSA-N- Molecular formula
- C59H84N16O12
- Average molar mass
- 1,209.4 g/mol
- Monoisotopic mass
- 1,208.64546218
Names & identifiers
- Preferred name
- Leuprelin Acetate
- IUPAC
- N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
- English name
- Leuprorelin
- Molecular formula
- C59H84N16O12
- Molecular weight
- 1209.4
Names & synonyms
Leuprelin Acetate(D-SER4)-LEUPROLIDELeuprorelin (INN)Leuprolide (USAN)Enantone (TN)SCHEMBL3036508SCHEMBL10061885SCHEMBL22555626NS00003681C07612D08113L001094
Show more names
LEUPROLIDELucrinLeuplina-43818CarcinilEnantonenghormoneLEUPRORELINLEUPROPELINLeuprorelinum
L002030
Database identifiers
- CAS
53714-56-0- PubChem CID
- 3911
Properties
Computed structural properties
- XLogP
- 0.7
- Topological polar surface area
- 432 Ų
- Hydrogen bond donors
- 15
- Hydrogen bond acceptors
- 14
- Rotatable bonds
- 32
- Heavy atoms
- 87
- Formal charge
- 0
- Complexity
- 2,390
Experimental & physicochemical properties
DrugsPharmaceuticals
Physicochemical properties
- alpha
- 25 · D25 -31.7° (c = 1 in 1% acetic acid)
- Density
- 1.44 · 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 9.82 · 9.82±0.15(Predicted)
- Water Solubility
- 1 mg/ml · Soluble in water at 1mg/ml
- Stability
- Hygroscopic
- InChIKey
- RGLRXNKKBLIBQS-VAZQWRJQNA-N
- CAS DataBase Reference
- 53714 · 53714-56-0(CAS DataBase Reference)
- FDA UNII
- 6 W0M8TG · EFY6W0M8TG
- ATC code
- 2 AE02 · L02AE02
- Symbol(GHS)
- 8 · GHS08
- Signal word
- Danger
- Hazard statements
- 360 · H360
- Precautionary statements
- 201 · P201-P280-P308+P313
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 2 · 2
- RTECS
- 6390000 · OH6390000
- Hazardous Substances Data
- 53714 · 53714-56-0(Hazardous Substances Data)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 2
- rtecs
- OH6390000
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- safety_code
- 22-24/25
- Hazard statements
- H360
- Precautionary statements
- P201-P280-P308+P313
- Hazardous Substances Data
- 53714-56-0(Hazardous Substances Data)
Chemistry & industry
Applications
DescriptionLeuprorelin(Leuprolide ) is a synthetic water-soluble nonapeptide with both ends closed, and also a highly active analogue of luteinizing hormone releasing hormone (LHRH or GnRH) produced by the hypothalamus. It can stimulate the pituitary gland to secrete gonadotropins and induce the production of steroids in the reproductive organs.
UsesLeuprorelin is a nonapeptide synthetic analogue of gonadotropin (GnRH), which can promote the release of luteinizing hormone (LHRH) and follicle stimulating hormone (FSH) from the anterior pituitary, regulate the secretion of gonadal hormones, and increase the serum levels of testosterone and dihydrotestosterone. Concentration, so as to achieve the function of treating reproductive system diseases. It is used to treat prostate cancer, uterine fibroids, ovarian cysts, breast cancer and cryptorchidism in children.
UsesHighly active luteinizing hormone releasing hormone (LHRH) agonist
UsesGonadotropin releasing hormone (gonadorelin) analogue; treatment of prostate cancer.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
上海沛灵生物科技有限公司13127581762 13127581762 · [email protected]
Shochem(Shanghai) Co.,Ltd86-21-50800795 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
湖北海克斯生化有限公司18696113233 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
浙江华军药业有限公司0571-17315361885 17315361885 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
石家庄感拓生物科技有限公司[email protected]
上海波以尔化工有限公司[email protected]
宁波亿诺化学品有限公司86-574-27787657 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
西安泽邦生物科技有限公司[email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
上海升华医药科技有限公司021-50793966 18917198199 · [email protected]
HONG KONG IPURE BIOLOGY CO.,LIMITED86 18062405514 18062405514 · [email protected]
合肥赛曼诺生物科技有限公司0551-65326643 18156095617 · [email protected]
南京生利德生物科技有限公司025-57798810 18652991625 · [email protected]
南京世洲生物科技有限公司13675144456 · [email protected]
湖北鑫源顺医药化工有限公司13971561712, 13995564702, 027-50664929 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
雷丁试剂0510-85629785 18013409632 · [email protected]
上海御略医药科技有限公司021-60345187 13671753212 · [email protected]
上海寰川实业有限公司021-61478794 · [email protected]
上海孚一生物科技有限公司+86 (21) 61124340
凯试（上海）科技有限公司021-50135380 · [email protected]
台州市科德化工有限公司0576-84613060 13093829633;13736603231 · [email protected]
浙江湃肽生物股份有限公司0571-89197072; 18668118770 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
上海楼岚生物科技有限公司021-52996696，15000506266 15000506266
珠海安哲生物科技有限公司13169972583 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
江苏诺泰澳赛诺生物制药股份有限公司0571-86297909 15268405618 · [email protected]
Beijing Yibai Biotechnology Co., Ltd0086-182-6772-3597 · [email protected]
湖北万业众诚化学试剂有限责任公司18671296875 · [email protected]
上海珞珐生化科技有限公司021-51111890 15317326293 · [email protected]
上海岚克医药科技发展有限公司0086-21-58956006
合肥赛曼诺生物科技有限公司0551-65326643 18156095617 · [email protected]
上海正严化学科技有限公司17802107445
上海前衍生物科技有限公司02781293128 · [email protected]
南京博米尔生物科技有限公司025-83453382-8005 · [email protected]
安泰精细化工技术有限公司18503026267 · [email protected]
武汉魔力生物科技有限公司18872289958、027-52304252、3400508168 · [email protected]
广州卡芬生物科技有限公司18029243487 2355327168 · [email protected]
凯立德生物医药技术（上海）有限公司021-58180488 · [email protected]
苏州爱玛特生物科技有限公司0512-56316828 400-867-5858;400-867-5858 · [email protected]
Adachibio Inc.+81-8027837258 · [email protected]
Additional notes
DefinitionChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. Leuprorelin is a synthetic nonapeptide analogue of gonadotropin-releasi g hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Related reactions
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Compound notes
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